| Literature DB >> 17457362 |
Daniel Roncone1, Anjali Satoskar, Tibor Nadasdy, J Paul Monk, Brad H Rovin.
Abstract
BACKGROUND: A 59-year-old man who had undergone a left nephrectomy for renal cell carcinoma was found to have metastatic disease during a restaging examination. The patient was started on treatment with interferon alpha2b plus bevacizumab, a humanized monoclonal anti-vascular endothelial growth factor antibody. After 9 months of this therapy, the patient developed proteinuria, which gradually increased to over 6 g/day. INVESTIGATIONS: Physical examination, urine and blood analysis, biopsy of the right kidney, and histologic evaluation of the non-neoplastic portion of the left nephrectomy specimen. DIAGNOSIS: Thrombotic microangiopathy and IgA immune-complex deposition in the glomerular capillary walls and mesangium. MANAGEMENT: Discontinuation of interferon alpha2b and bevacizumab, control of blood pressure with an angiotensin-converting-enzyme inhibitor and an angiotensin-receptor blocker.Entities:
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Year: 2007 PMID： 17457362 DOI： 10.1038/ncpneph0476
Source DB: PubMed Journal: Nat Clin Pract Nephrol ISSN： 1745-8323