OBJECTIVE: To construct and analyze a database comprised of all reported cases of primary breast lymphoma (PBL) that include treatment and follow-up information published during the last 3 decades. SUMMARY BACKGROUND DATA: PBL accounts for 0.4% of breast malignancies and 2% of extranodal lymphomas. Surgical therapy has varied from biopsy to radical mastectomy. Chemotherapy and radiation therapy have been used as adjuvant or primary therapy. A standard consensus treatment of PBL is not available. METHODS: We reviewed all published PBL reports from June 1972 to March 2005. A database was compiled by abstracting individual patient information, limiting our study to those reports that contained specific treatment and outcome data. Patient demographics such as survival, recurrence, and time to follow-up were recorded, in addition to surgical, radiation, and/or chemotherapy treatment(s). RESULTS: We found 465 acceptable patients reported in 92 publications. Age range was 17 to 95 years (mean, 54 years). Mean tumor size was 3.5 cm. Diffuse large cell (B) lymphoma was the most common histologic diagnosis (53%). Disease-free survival was 44.5% overall. Follow-up ranged from one to 288 months (mean, 48 months). Treatment by mastectomy offered no survival benefit or protection from recurrence. Treatment that included radiation therapy in stage I patients (node negative) showed benefit in both survival and recurrence rates. Treatment that included chemotherapy in stage II patients (node positive) showed benefit in both survival and recurrence rates. Histologic tumor grade predicted survival. CONCLUSIONS: Mastectomy offers no benefit in the treatment of PBL. Nodal status predicts outcome and guides optimal use of radiation and chemotherapy.
OBJECTIVE: To construct and analyze a database comprised of all reported cases of primary breast lymphoma (PBL) that include treatment and follow-up information published during the last 3 decades. SUMMARY BACKGROUND DATA: PBL accounts for 0.4% of breast malignancies and 2% of extranodal lymphomas. Surgical therapy has varied from biopsy to radical mastectomy. Chemotherapy and radiation therapy have been used as adjuvant or primary therapy. A standard consensus treatment of PBL is not available. METHODS: We reviewed all published PBL reports from June 1972 to March 2005. A database was compiled by abstracting individual patient information, limiting our study to those reports that contained specific treatment and outcome data. Patient demographics such as survival, recurrence, and time to follow-up were recorded, in addition to surgical, radiation, and/or chemotherapy treatment(s). RESULTS: We found 465 acceptable patients reported in 92 publications. Age range was 17 to 95 years (mean, 54 years). Mean tumor size was 3.5 cm. Diffuse large cell (B) lymphoma was the most common histologic diagnosis (53%). Disease-free survival was 44.5% overall. Follow-up ranged from one to 288 months (mean, 48 months). Treatment by mastectomy offered no survival benefit or protection from recurrence. Treatment that included radiation therapy in stage I patients (node negative) showed benefit in both survival and recurrence rates. Treatment that included chemotherapy in stage II patients (node positive) showed benefit in both survival and recurrence rates. Histologic tumor grade predicted survival. CONCLUSIONS: Mastectomy offers no benefit in the treatment of PBL. Nodal status predicts outcome and guides optimal use of radiation and chemotherapy.
Authors: Alexandra Thomas; Brian K Link; Sean Altekruse; Paul A Romitti; Mary C Schroeder Journal: J Natl Cancer Inst Date: 2017-06-01 Impact factor: 13.506
Authors: Peter J Hosein; Jocelyn C Maragulia; Matthew P Salzberg; Oliver W Press; Thomas M Habermann; Julie M Vose; Martin Bast; Ranjana H Advani; Robert Tibshirani; Andrew M Evens; Nahida Islam; John P Leonard; Peter Martin; Andrew D Zelenetz; Izidore S Lossos Journal: Br J Haematol Date: 2014-01-27 Impact factor: 6.998
Authors: Nicola Avenia; Alessandro Sanguinetti; Roberto Cirocchi; Giovanni Bistoni; Stefano Trastulli; Fabio D'Ajello; Francesco Barberini; Giuseppe Cavallaro; Antonio Rulli; Angelo Sidoni; Giuseppe Noya; Giorgio De Toma; Francesco Sciannameo Journal: World J Surg Oncol Date: 2010-06-28 Impact factor: 2.754
Authors: Narcis Octavian Zarnescu; Andreea Iliesiu; Alexandru Procop; Mircea Tampa; Clara Matei; Maria Sajin; Mariana Costache; Adrian Dumitru; Anca Mihaela Lazaroiu Journal: Maedica (Buchar) Date: 2015-03