Literature DB >> 1745706

Reversal by tetrahydroaminoacridine of scopolamine-induced memory and performance deficits in rats.

T K Murray1, A J Cross, A R Green.   

Abstract

The effects of the cholinesterase inhibitors physostigmine and tetrahydroaminoacridine (THA) on memory and performance deficits induced by scopolamine were studied using an operant delayed non-matching to position task. No effect was seen on the performance of rats when treated with either physostigmine (0.1 mg/kg IP) or THA (1 mg/kg IP) alone. However, the performance deficits induced in the task by scopolamine (0.03 mg/kg SC) were reversed by the same doses of the cholinesterase inhibitors.

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Year:  1991        PMID： 1745706     DOI： 10.1007/bf02316877

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  14 in total

1.  Evidence for a direct cholinergic involvement in the scopolamine-induced amnesia in monkeys: effects of concurrent administration of physostigmine and methylphenidate with scopolamine.

Authors:  R T Bartus
Journal:  Pharmacol Biochem Behav       Date:  1978-12       Impact factor: 3.533

2.  Effects of nicotine, oxotremorine and 9-amino 1,2,3,4- tetrahydroacridine (tacrine) on matching and non matching to position in rats: no evidence for mnemonic enhancement.

Authors:  A Sahgal; A B Keith; S Lloyd
Journal:  J Psychopharmacol       Date:  1990-01       Impact factor: 4.153

3.  The effects of cholinergic drugs upon recognition memory in rats.

Authors:  A E Huston; J P Aggleton
Journal:  Q J Exp Psychol B       Date:  1987-11

4.  Comparative effects of cholinergic drugs and lesions of nucleus basalis or fimbria-fornix on delayed matching in rats.

Authors:  S B Dunnett
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

5.  Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies.

Authors:  D M Bowen; C B Smith; P White; A N Davison
Journal:  Brain       Date:  1976-09       Impact factor: 13.501

6.  Tetrahydroaminoacridine, 3,4 diaminopyridine and physostigmine: direct comparison of effects on memory in aged primates.

Authors:  R T Bartus; R L Dean
Journal:  Neurobiol Aging       Date:  1988 Jul-Aug       Impact factor: 4.673

7.  Oral physostigmine treatment of patients with Alzheimer's disease.

Authors:  R C Mohs; B M Davis; C A Johns; A A Mathé; B S Greenwald; T B Horvath; K L Davis
Journal:  Am J Psychiatry       Date:  1985-01       Impact factor: 18.112

8.  Hemicholinium-3 impairs spatial learning and the deficit is reversed by cholinomimetics.

Authors:  J J Hagan; J H Jansen; C L Broekkamp
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

9.  Contrasting effects of vasopressin, desglycinamide-vasopressin and amphetamine on a delayed matching to position task in rats.

Authors:  A Sahgal
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

10.  Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type.

Authors:  W K Summers; L V Majovski; G M Marsh; K Tachiki; A Kling
Journal:  N Engl J Med       Date:  1986-11-13       Impact factor: 91.245
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  7 in total

1.  Attenuation of scopolamine-induced spatial memory deficits in the rat by cholinomimetic and non-cholinomimetic drugs using a novel task in the 12-arm radial maze.

Authors:  R P Dennes; J C Barnes
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

2.  Phenserine: a physostigmine derivative that is a long-acting inhibitor of cholinesterase and demonstrates a wide dose range for attenuating a scopolamine-induced learning impairment of rats in a 14-unit T-maze.

Authors:  S Iijima; N H Greig; P Garofalo; E L Spangler; B Heller; A Brossi; D K Ingram
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

3.  MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice.

Authors:  S Murai; H Saito; E Abe; Y Masuda; J Odashima; T Itoh
Journal:  J Neural Transm Gen Sect       Date:  1994

4.  A comparison of the effects of the novel muscarinic receptor agonists L-689,660 and AF102B in tests of reference and working memory.

Authors:  G R Dawson; P Bayley; S Channell; S D Iversen
Journal:  Psychopharmacology (Berl)       Date:  1994-01       Impact factor: 4.530

Review 5.  Tacrine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in Alzheimer's disease.

Authors:  A J Wagstaff; D McTavish
Journal:  Drugs Aging       Date:  1994-06       Impact factor: 3.923

6.  Velnacrine maleate improves delayed matching performance by aged monkeys.

Authors:  W J Jackson; J J Buccafusco; A V Terry; D J Turk; D K Rush
Journal:  Psychopharmacology (Berl)       Date:  1995-06       Impact factor: 4.530

7.  Multifunctionality of Clausena harmandiana Extract and Its Active Constituents against Alzheimer's Disease.

Authors:  Chantana Boonyarat; Chavi Yenjai; Orawan Monthakantirat; Rawiwun Kaewamatawong; Pattaporn Poonsawas; Jinda Wangboonskul; Suchada Chaiwiwatrakul; Pornthip Waiwut
Journal:  Curr Issues Mol Biol       Date:  2022-08-15       Impact factor: 2.976
  7 in total

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