BACKGROUND: Studies suggest that brain reserve allows patients with more years of schooling to cope better with brain damage. Research has been mainly focussed on Alzheimer's disease and no studies exist on patients with dementia with Lewy bodies (DLB). The aim of this study was to provide evidence for brain reserve in DLB. METHODS: Twenty-one consecutive patients with DLB and 16 age-matched healthy controls were included. The participants underwent cerebral (18)F-FDG PET imaging at rest. A group comparison was conducted in SPM2 between the patient and control groups. A linear regression analysis with glucose metabolism as the dependent and years of schooling as the independent variable was performed. Age, gender and a total score of the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery were included as covariates into the analysis. RESULTS: The patients showed a significant metabolic reduction in the frontal and posterior association cortices, the basal ganglia and the pulvinar of the thalami. Glucose metabolism and education showed an inverse relationship in an extensive cluster in the left temporo-parieto-occipital cortex. CONCLUSION: Similar findings were previously reported in Alzheimer's disease and are regarded as evidence for brain reserve. Therefore, we suggest that brain reserve is also present in DLB.
BACKGROUND: Studies suggest that brain reserve allows patients with more years of schooling to cope better with brain damage. Research has been mainly focussed on Alzheimer's disease and no studies exist on patients with dementia with Lewy bodies (DLB). The aim of this study was to provide evidence for brain reserve in DLB. METHODS: Twenty-one consecutive patients with DLB and 16 age-matched healthy controls were included. The participants underwent cerebral (18)F-FDG PET imaging at rest. A group comparison was conducted in SPM2 between the patient and control groups. A linear regression analysis with glucose metabolism as the dependent and years of schooling as the independent variable was performed. Age, gender and a total score of the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery were included as covariates into the analysis. RESULTS: The patients showed a significant metabolic reduction in the frontal and posterior association cortices, the basal ganglia and the pulvinar of the thalami. Glucose metabolism and education showed an inverse relationship in an extensive cluster in the left temporo-parieto-occipital cortex. CONCLUSION: Similar findings were previously reported in Alzheimer's disease and are regarded as evidence for brain reserve. Therefore, we suggest that brain reserve is also present in DLB.
Authors: María C Rodriguez-Oroz; Belen Gago; Pedro Clavero; Manuel Delgado-Alvarado; David Garcia-Garcia; Haritz Jimenez-Urbieta Journal: Curr Neurol Neurosci Rep Date: 2015-07 Impact factor: 5.081
Authors: R Perneczky; S Wagenpfeil; K L Lunetta; L A Cupples; R C Green; C Decarli; L A Farrer; A Kurz Journal: Neurology Date: 2010-07-13 Impact factor: 9.910
Authors: Robert Perneczky; Stefan Wagenpfeil; Kathryn L Lunetta; L Adrienne Cupples; Robert C Green; Charles DeCarli; Lindsay A Farrer; Alexander Kurz Journal: J Alzheimers Dis Date: 2009 Impact factor: 4.472
Authors: Daniel Erskine; Jinhui Ding; Alan J Thomas; Alice Kaganovich; Ahmad A Khundakar; Peter S Hanson; John-Paul Taylor; Ian G McKeith; Johannes Attems; Mark R Cookson; Christopher M Morris Journal: Mov Disord Date: 2018-03-23 Impact factor: 10.338
Authors: Robert Perneczky; Gerd Kempermann; Amos D Korczyn; Fiona E Matthews; M Arfan Ikram; Nikolaos Scarmeas; Gael Chetelat; Yaakov Stern; Michael Ewers Journal: BMC Med Date: 2019-02-27 Impact factor: 8.775
Authors: Stefan Klöppel; Jessica Peter; Anna Ludl; Anne Pilatus; Sabrina Maier; Irina Mader; Bernhard Heimbach; Lars Frings; Karl Egger; Juergen Dukart; Matthias L Schroeter; Robert Perneczky; Peter Häussermann; Werner Vach; Horst Urbach; Stefan Teipel; Michael Hüll; Ahmed Abdulkadir Journal: J Alzheimers Dis Date: 2015 Impact factor: 4.472
Authors: Stefan Klöppel; Shan Yang; Elias Kellner; Marco Reisert; Bernhard Heimbach; Horst Urbach; Jennifer Linn; Stefan Weidauer; Tamara Andres; Maximilian Bröse; Jacob Lahr; Niklas Lützen; Philipp T Meyer; Jessica Peter; Ahmed Abdulkadir; Sabine Hellwig; Karl Egger Journal: Neuroimage Clin Date: 2018-09-19 Impact factor: 4.881