| Literature DB >> 17456980 |
Ellen Graf1, Kathrin Schneider, Graeme Nicholson, Markus Ströbele, Amanda L Jones, Michael Goodfellow, Winfried Beil, Roderich D Süssmuth, Hans-Peter Fiedler.
Abstract
Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.Entities:
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Year: 2007 PMID： 17456980 DOI： 10.1038/ja.2007.35
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649