| Literature DB >> 17456975 |
Yoshihide Matsuo1, Kaneo Kanoh, Takao Yamori, Hiroaki Kasai, Atsuko Katsuta, Kyoko Adachi, Kazuo Shin-Ya, Yoshikazu Shizuri.
Abstract
Urukthapelstatin A, a novel cyclic peptide, was isolated from the cultured mycelia of marine-derived Thermoactinomycetaceae bacterium Mechercharimyces asporophorigenens YM11-542. The peptide was purified by solvent extraction, silica gel chromatography, ODS flash chromatography, and finally by preparative HPLC. Urukthapelstatin A dose-dependently inhibited the growth of human lung cancer A549 cells with an IC(50) value of 12 nM. Urukthapelstatin A also showed potent cytotoxic activity against a human cancer cell line panel.Entities:
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Year: 2007 PMID： 17456975 DOI： 10.1038/ja.2007.30
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649