PURPOSE: The contribution of genetic factors in the persistence of and early recovery from stuttering was assessed. METHOD: Data from the Twins Early Development Study were employed. Parental reports regarding stuttering were collected at ages 2, 3, 4, and 7 years, and were used to classify speakers into recovered and persistent groups. Of 12,892 children with at least 2 ratings, 950 children had recovered and 135 persisted in their stutter. RESULTS: Logistic regressions showed that the rating at age 2 was not predictive of later stuttering, whereas ratings at ages 3 and 4 were. Concordance rates were consistently higher for monozygotic than for dizygotic twin pairs (with the exception of girls at age 3). At 3, 4, and 7 years, the liability to stuttering was highly heritable (h2 estimates of between .58 and .66). Heritability for the recovered and persistent groups was also high but did not differ from each other. CONCLUSION: Stuttering appears to be a disorder that has high heritability and little shared environment effect in early childhood and for recovered and persistent groups of children, by age 7. The clinical implications of the findings are discussed.
PURPOSE: The contribution of genetic factors in the persistence of and early recovery from stuttering was assessed. METHOD: Data from the Twins Early Development Study were employed. Parental reports regarding stuttering were collected at ages 2, 3, 4, and 7 years, and were used to classify speakers into recovered and persistent groups. Of 12,892 children with at least 2 ratings, 950 children had recovered and 135 persisted in their stutter. RESULTS: Logistic regressions showed that the rating at age 2 was not predictive of later stuttering, whereas ratings at ages 3 and 4 were. Concordance rates were consistently higher for monozygotic than for dizygotic twin pairs (with the exception of girls at age 3). At 3, 4, and 7 years, the liability to stuttering was highly heritable (h2 estimates of between .58 and .66). Heritability for the recovered and persistent groups was also high but did not differ from each other. CONCLUSION: Stuttering appears to be a disorder that has high heritability and little shared environment effect in early childhood and for recovered and persistent groups of children, by age 7. The clinical implications of the findings are discussed.
Authors: Yin Yao Shugart; Jennifer Mundorff; James Kilshaw; Kimberly Doheny; Betty Doan; Jacqueline Wanyee; Eric D Green; Dennis Drayna Journal: Am J Med Genet A Date: 2004-01-15 Impact factor: 2.802
Authors: M Hashim Raza; Rafael Mattera; Robert Morell; Eduardo Sainz; Rachel Rahn; Joanne Gutierrez; Emily Paris; Jessica Root; Beth Solomon; Carmen Brewer; M Asim Raza Basra; Shaheen Khan; Sheikh Riazuddin; Allen Braun; Juan S Bonifacino; Dennis Drayna Journal: Am J Hum Genet Date: 2015-11-05 Impact factor: 11.025
Authors: Changsoo Kang; Sheikh Riazuddin; Jennifer Mundorff; Donna Krasnewich; Penelope Friedman; James C Mullikin; Dennis Drayna Journal: N Engl J Med Date: 2010-02-10 Impact factor: 91.245
Authors: M Hashim Raza; E Michael Gertz; Jennifer Mundorff; Joseph Lukong; Judith Kuster; Alejandro A Schäffer; Dennis Drayna Journal: Hum Genet Date: 2012-12-13 Impact factor: 4.132