Literature DB >> 17455978

Aurantiomides A-C, quinazoline alkaloids from the sponge-derived fungus Penicillium aurantiogriseum SP0-19.

Zhi Hong Xin1, Yuchun Fang, Lin Du, Tianjiao Zhu, Lin Duan, Juan Chen, Qian-Qun Gu, Wei-Ming Zhu.   

Abstract

Three new quinazoline alkaloids, aurantiomides A (1), B (2), and C (3), along with the known metabolite anacine (4) were isolated from the sponge-derived fungus strain Penicillium aurantiogriseum SP0-19 by bioassay-guided fractionation. Their structures were elucidated by spectroscopic and chemical methods. Their absolute configurations were deduced by comparison of their Cotton effects with anacine (4) and by chemical transformations. Compounds 2 and 3 showed moderate cytotoxicities against HL-60, P388 and BEL-7402, P388 cell lines, respectively.

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Year:  2007        PMID： 17455978     DOI： 10.1021/np060516h

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  16 in total

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Journal:  Mar Drugs       Date:  2013-12-13       Impact factor: 5.118

Review 6.  Bioactive Compounds Produced by Strains of Penicillium and Talaromyces of Marine Origin.

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Journal:  Mar Drugs       Date:  2017-03-10       Impact factor: 5.118

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Journal:  Mar Drugs       Date:  2016-07-14       Impact factor: 5.118
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