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Literature DB >> 17455939

Total synthesis of archazolid A.

Dirk Menche¹, Jorma Hassfeld, Jun Li, Sven Rudolph.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17455939 DOI： 10.1021/ja071461o

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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19 in total

1. MDM2 antagonist nutlin-3a sensitizes tumors to V-ATPase inhibition.

Authors: Lina S Schneider; Melanie Ulrich; Thorsten Lehr; Dirk Menche; Rolf Müller; Karin von Schwarzenberg
Journal: Mol Oncol Date: 2016-04-27 Impact factor: 6.603

2. Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibition.

Authors: Karin von Schwarzenberg; Romina M Wiedmann; Prajakta Oak; Sabine Schulz; Hans Zischka; Gerhard Wanner; Thomas Efferth; Dirk Trauner; Angelika M Vollmar
Journal: J Biol Chem Date: 2012-11-20 Impact factor: 5.157

3. Archazolid A binds to the equatorial region of the c-ring of the vacuolar H+-ATPase.

Authors: Svenja Bockelmann; Dirk Menche; Sven Rudolph; Tobias Bender; Stephanie Grond; Paultheo von Zezschwitz; Stephen P Muench; Helmut Wieczorek; Markus Huss
Journal: J Biol Chem Date: 2010-09-30 Impact factor: 5.157

4. Alkyne elementometalation-Pd-catalyzed cross-coupling. Toward synthesis of all conceivable types of acyclic alkenes in high yields, efficiently, selectively, economically, and safely: "green" way.

Authors: Ei-Ichi Negishi; Guangwei Wang; Honghua Rao; Zhaoqing Xu
Journal: J Org Chem Date: 2010-05-21 Impact factor: 4.354

5. Synthesis of a C₁-C₂₃ fragment of the archazolids and evidence for V-ATPase but not COX inhibitory activity.

Authors: Gregory W O'Neil; Alexander M Craig; John R Williams; Jeffrey C Young; P Clint Spiegel
Journal: Synlett Date: 2017-02-08 Impact factor: 2.454

6. Highly stereo- and regioselective synthesis of (Z)-trisubstituted alkenes via 1-bromo-1-alkyne hydroboration-migratory insertion-Zn-promoted iodinolysis and Pd-catalyzed organozinc cross-coupling.

Authors: Zhihong Huang; Ei-ichi Negishi
Journal: J Am Chem Soc Date: 2007-11-07 Impact factor: 15.419

Total synthesis of archazolid A.

1. MDM2 antagonist nutlin-3a sensitizes tumors to V-ATPase inhibition.

2. Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibition.

3. Archazolid A binds to the equatorial region of the c-ring of the vacuolar H+-ATPase.

4. Alkyne elementometalation-Pd-catalyzed cross-coupling. Toward synthesis of all conceivable types of acyclic alkenes in high yields, efficiently, selectively, economically, and safely: "green" way.

5. Synthesis of a C₁-C₂₃ fragment of the archazolids and evidence for V-ATPase but not COX inhibitory activity.

6. Highly stereo- and regioselective synthesis of (Z)-trisubstituted alkenes via 1-bromo-1-alkyne hydroboration-migratory insertion-Zn-promoted iodinolysis and Pd-catalyzed organozinc cross-coupling.

7. Synthesis of the C₁-C₁₇ fragment of the archazolids by complex cis-homodimer cross metathesis.

8. Efficient synthesis of the C(7)-C(20) subunit of amphidinolides C and F.

9. Exploiting hidden symmetry in natural products: total syntheses of amphidinolides C and F.

10. Anti-leukemic effects of the V-ATPase inhibitor Archazolid A.