Efficient co-crystal screening using solution-mediated phase transformation.

We have extended the established physical stability treatment for hydrates/solvates to co-crystals with solid co-crystal formers. Based on the proposed treatment, a suspension/slurry screening technique is developed and tested in sixteen pharmaceutical co-crystal systems with success. The theoretical treatment and the practical screening technique should benefit the researchers in the field of co-crystallization in improving the screening efficiency. (c) 2007 Wiley-Liss, Inc. and the American Pharmacists Association.