BACKGROUND: Published data support genetic variants, as well as certain infectious agents, as potential risk factors for schizophrenia. Less is known about interactions between the risk factors. AIM: To evaluate exposure to infectious agents and host genetic variation as joint risk factors. METHODS: We investigated four infectious agents: cytomegalovirus (CMV), herpes simplex viruses 1 and 2 (HSV1, HSV2), and Toxoplasma gondii (TOX). We initially compared exposure using specific serum antibodies, among simplex and multiplex nuclear families (one or more than one affected offspring, respectively). If interactions between infectious agents and host genetic variation are important risk factors for schizophrenia, we reasoned that they would be more prominent among multiplex versus simplex families. We also evaluated the role of variation at chromosome 6p21-p23 in conjunction with exposure. We used 22 short tandem repeat polymorphisms (STRPs) dispersed across this region. RESULTS: Though exposure to all four agents was increased among multiplex families versus simplex families, the difference was consistently significant only for CMV (odds of exposure to CMV in multiplex families: 2.47, 95% CI: 1.48-5.33). Transmission disequilibrium tests and case-control comparisons using STRPs revealed significant linkage/association with D6S2672 among CMV+ schizophrenia patients. CONCLUSIONS: Polymorphisms near D6S2672 could confer risk for schizophrenia in conjunction with CMV exposure.
BACKGROUND: Published data support genetic variants, as well as certain infectious agents, as potential risk factors for schizophrenia. Less is known about interactions between the risk factors. AIM: To evaluate exposure to infectious agents and host genetic variation as joint risk factors. METHODS: We investigated four infectious agents: cytomegalovirus (CMV), herpes simplex viruses 1 and 2 (HSV1, HSV2), and Toxoplasma gondii (TOX). We initially compared exposure using specific serum antibodies, among simplex and multiplex nuclear families (one or more than one affected offspring, respectively). If interactions between infectious agents and host genetic variation are important risk factors for schizophrenia, we reasoned that they would be more prominent among multiplex versus simplex families. We also evaluated the role of variation at chromosome 6p21-p23 in conjunction with exposure. We used 22 short tandem repeat polymorphisms (STRPs) dispersed across this region. RESULTS: Though exposure to all four agents was increased among multiplex families versus simplex families, the difference was consistently significant only for CMV (odds of exposure to CMV in multiplex families: 2.47, 95% CI: 1.48-5.33). Transmission disequilibrium tests and case-control comparisons using STRPs revealed significant linkage/association with D6S2672 among CMV+ schizophreniapatients. CONCLUSIONS: Polymorphisms near D6S2672 could confer risk for schizophrenia in conjunction with CMV exposure.
Authors: Konasale M Prasad; Mikhil N Bamne; Brian H Shirts; Dhruman Goradia; Vimal Mannali; Krishna M Pancholi; Bai Xue; Lora McClain; Robert H Yolken; Matcheri S Keshavan; Vishwajit L Nimgaonkar Journal: Schizophr Res Date: 2010-02-06 Impact factor: 4.939
Authors: Mikhil Bamne; Joel Wood; Kodavali Chowdari; Annie M Watson; Cemil Celik; Hader Mansour; Lambertus Klei; Ruben C Gur; L DiAnne Bradford; Monica E Calkins; Alberto B Santos; Neil Edwards; Joseph Kwentus; Joseph P McEvoy; Trina B Allen; Robert M Savage; Henry A Nasrallah; Raquel E Gur; Rodney T Perry; Rodney C P Go; Bernie Devlin; Robert Yolken; Vishwajit L Nimgaonkar Journal: Schizophr Bull Date: 2012-09-10 Impact factor: 9.306
Authors: A R Prossin; R H Yolken; M Kamali; M M Heitzeg; J B Kaplow; W H Coryell; M G McInnis Journal: Neural Plast Date: 2015-05-13 Impact factor: 3.599
Authors: A D Børglum; D Demontis; J Grove; J Pallesen; M V Hollegaard; C B Pedersen; A Hedemand; M Mattheisen; A Uitterlinden; M Nyegaard; T Ørntoft; C Wiuf; M Didriksen; M Nordentoft; M M Nöthen; M Rietschel; R A Ophoff; S Cichon; R H Yolken; D M Hougaard; P B Mortensen; O Mors Journal: Mol Psychiatry Date: 2013-01-29 Impact factor: 15.992