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Literature DB >> 17452483

Sultam thiourea inhibition of West Nile virus.

Eric Barklis¹, Amelia Still, Mohammad I Sabri, Alec J Hirsch, Janko Nikolich-Zugich, James Brien, Tenzin Choesang Dhenub, Isabel Scholz, Ayna Alfadhli.

Abstract

We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 microM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.

Entities: Chemical Species

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Year: 2007 PMID： 17452483 PMCID： PMC1913232 DOI： 10.1128/AAC.00007-07

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

32 in total

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Journal: Antimicrob Agents Chemother Date: 2002-05 Impact factor: 5.191

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2. Design, synthesis, and in vitro evaluation of potential West Nile virus protease inhibitors based on the 1-oxo-1,2,3,4-tetrahydroisoquinoline and 1-oxo-1,2-dihydroisoquinoline scaffolds.

Authors: Dengfeng Dou; Prasanth Viwanathan; Yi Li; Guijia He; Kevin R Alliston; Gerald H Lushington; Joshua D Brown-Clay; R Padmanabhan; William C Groutas
Journal: J Comb Chem Date: 2010-09-30

2 in total