| Literature DB >> 17452255 |
Christine M Szych1, Jane L Liesveld, M Anwar Iqbal, LiQiong Li, Susan Siebert, Courtney Asmus, Julie O'Malley, Adam Lee, Nancy Wang.
Abstract
Amplification/duplication of the BCR-ABL gene has been found to be one of the key factors leading to drug resistance to imatinib mesylate (IM). In the present study, we used G-banding to identify the presence of de novo identical isodicentric chromosomes in IM-resistant patients. Fluorescence in situ hybridization (FISH) analysis on interphase nuclei confirmed the heterogeneity and amplification of the fused BCR-ABL gene. FISH analysis superimposed on G-banding confirmed the presence of isodicentric Philadelphia chromosomes. The impact of the isodicentric Philadelphia chromosomes on genomic instability, heterogeneity, and amplification of the Philadelphia chromosomes in IM-resistant patients is discussed.Entities:
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Year: 2007 PMID： 17452255 DOI： 10.1016/j.cancergencyto.2006.12.001
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608