Literature DB >> 17452253

"Home-brew" FISH assay shows higher efficiency than BCR-ABL dual color, dual fusion probe in detecting microdeletions and complex rearrangements associated with t(9;22) in chronic myeloid leukemia.

Francesco Albano1, Luisa Anelli, Antonella Zagaria, Nicoletta Archidiacono, Vincenzo Liso, Giorgina Specchia, Mariano Rocchi.   

Abstract

We carried out fluorescence in situ hybridization (FISH) studies on 18 Ph+ chronic myeloid leukemia (CML) cases with chromosome 22 genomic deletions with the Vysis BCR-ABL dual-color/dual-fusion probe (BCR-ABL DC/DF) to compare the hybridization patterns obtained with this approach to those obtained with the "home brew" BAC/PAC system. Our results are the following: chromosome 22 microdeletions less than 400 kilobases (Kb) were not detected by the BCR DC/DF probe; FISH analysis with the BCR DC/DF probe in cases bearing chromosome 22 microdeletions ranging from 400 to 700 Kb produced a faint signal on the der(9); and the BCR-ABL DC/DF FISH pattern was comparable to the one obtained by the home brew probe in the presence of a 900-Kb chromosome 22 microdeletion. Our home-brew FISH system represents an accurate method for revealing a subset of CML patients with der(9) microdeletions.

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Year:  2007        PMID： 17452253     DOI： 10.1016/j.cancergencyto.2006.09.025

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  6 in total

1.  BCR-ABL1 e6a2 transcript in chronic myeloid leukemia: biological features and molecular monitoring by droplet digital PCR.

Authors:  Antonella Zagaria; Luisa Anelli; Nicoletta Coccaro; Giuseppina Tota; Paola Casieri; Angelo Cellamare; Luciana Impera; Claudia Brunetti; Angela Minervini; Crescenzio Francesco Minervini; Mario Delia; Cosimo Cumbo; Paola Orsini; Giorgina Specchia; Francesco Albano
Journal:  Virchows Arch       Date:  2015-07-07       Impact factor: 4.064

2.  Molecular cytogenetic study of derivative chromosome 9 deletion in chronic myeloid leukemia patients.

Authors:  Ayda Bennour; Ines Ouahchi; Yosra Ben Youssef; Monia Zaier; Mohamed Adnéne Laatiri; Imed Harrabi; Balkis Meddeb; Moez Elloumi; Abderrahim Khelif; Ali Saad; Halima Sennana
Journal:  Med Oncol       Date:  2011-04-03       Impact factor: 3.064

3.  Non random distribution of genomic features in breakpoint regions involved in chronic myeloid leukemia cases with variant t(9;22) or additional chromosomal rearrangements.

Authors:  Francesco Albano; Luisa Anelli; Antonella Zagaria; Nicoletta Coccaro; Paola Casieri; Antonella Russo Rossi; Laura Vicari; Vincenzo Liso; Mariano Rocchi; Giorgina Specchia
Journal:  Mol Cancer       Date:  2010-05-25       Impact factor: 27.401

4.  Reliability Evaluation of Fluorescence In Situ Hybridization (FISH) and G-Banding on Bone Marrow and Peripheral Blood Cells in Chronic Myelogenous Leukemia Patients.

Authors:  Soheila Manaflouyan Khajehmarjany; Seyed Ali Rahmani; Seyed Hadi Chavoshi; Ali Esfahani; Ali Akbar Movassaghpour Akbari
Journal:  Cell J       Date:  2015-04-08       Impact factor: 2.479

5.  Skin lesions in chronic myeloid leukemia patients during dasatinib treatment.

Authors:  Francesco Tarantini; Luisa Anelli; Giuseppe Ingravallo; Immacolata Attolico; Antonella Zagaria; Antonella Russo Rossi; Lucia Lospalluti; Tamara Bufano; Giovanni Zanframundo; Eugenio Maiorano; Giorgina Specchia; Francesco Albano
Journal:  Cancer Manag Res       Date:  2019-08-26       Impact factor: 3.989

6.  Genomic BCR-ABL1 breakpoint characterization by a multi-strategy approach for "personalized monitoring" of residual disease in chronic myeloid leukemia patients.

Authors:  Cosimo Cumbo; Luciana Impera; Crescenzio Francesco Minervini; Paola Orsini; Luisa Anelli; Antonella Zagaria; Nicoletta Coccaro; Giuseppina Tota; Angela Minervini; Paola Casieri; Claudia Brunetti; Antonella Russo Rossi; Elisa Parciante; Giorgina Specchia; Francesco Albano
Journal:  Oncotarget       Date:  2018-01-05
  6 in total

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