OBJECTIVE: To determine whether increased thyroid hormones levels have an effect on various bone components (cortical vs cancellous bone). STUDY DESIGN: The anthropometric and 3-dimensional quantitative computed tomography (CT) bone measurements, including bone density (BD), cross-sectional area (CSA) of the lumbar spine and femur, and cortical bone area (CBA) of the femur, of 18 children and adolescents with untreated hyperthyroidism were reviewed and compared with those of age-, sex-, and ethnicity-matched historical controls. RESULTS: No significant differences in height, weight, body mass index (BMI), or pubertal staging between patients and controls were found. Cortical BD was significantly lower (P < .001) in children and adolescents with hyperthyroidism compared with historical controls. After adjusting for weight and height, no difference in femur CSA between hyperthyroid children and historical controls was evident. No significant correlations among thyroid hormone levels, antithyroid antibody levels, and cortical BD values were found. CONCLUSIONS: As determined by CT, cortical bone is the preferential site of bone loss in children and adolescents with untreated hyperthyroidism.
OBJECTIVE: To determine whether increased thyroid hormones levels have an effect on various bone components (cortical vs cancellous bone). STUDY DESIGN: The anthropometric and 3-dimensional quantitative computed tomography (CT) bone measurements, including bone density (BD), cross-sectional area (CSA) of the lumbar spine and femur, and cortical bone area (CBA) of the femur, of 18 children and adolescents with untreated hyperthyroidism were reviewed and compared with those of age-, sex-, and ethnicity-matched historical controls. RESULTS: No significant differences in height, weight, body mass index (BMI), or pubertal staging between patients and controls were found. Cortical BD was significantly lower (P < .001) in children and adolescents with hyperthyroidism compared with historical controls. After adjusting for weight and height, no difference in femur CSA between hyperthyroid children and historical controls was evident. No significant correlations among thyroid hormone levels, antithyroid antibody levels, and cortical BD values were found. CONCLUSIONS: As determined by CT, cortical bone is the preferential site of bone loss in children and adolescents with untreated hyperthyroidism.
Authors: Graziella Mendonça Monteiro de Barros; Miguel Madeira; Leonardo Vieira Neto; Francisco de Paula Paranhos Neto; Laura Maria Carvalho Mendonça; Inayá Corrêa Barbosa Lima; Rossana Corbo; Maria Lucia Fleiuss Farias Journal: J Bone Miner Metab Date: 2015-06-09 Impact factor: 2.626
Authors: Hassan M Salama; Soha A El-Dayem; Hala Yousef; Ashraf Fawzy; Laila Abou-Ismail; Dalia El-Lebedy Journal: Arch Med Sci Date: 2010-06-30 Impact factor: 3.318