| Literature DB >> 17451954 |
Jeff A O'Meara1, Araz Jakalian, Steven LaPlante, Pierre R Bonneau, René Coulombe, Anne-Marie Faucher, Ingrid Guse, Serge Landry, Jennifer Racine, Bruno Simoneau, Bounkham Thavonekham, Christiane Yoakim.
Abstract
High-throughput screening hit 1 was identified as a potent, broad-spectrum, non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 replication. Analysis of the bound conformation of analogs of this inhibitor via molecular modeling and NMR contributed to the design of novel tertiary amide, carbamate, and thiocarbamate based NNRTIs.Entities:
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Year: 2007 PMID： 17451954 DOI： 10.1016/j.bmcl.2007.03.097
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823