| Literature DB >> 17451832 |
Seung-Ho Hong1, Okki Cho, Koyngmin Kim, Ho-Joon Shin, Sergei V Kotenko, Sun Park.
Abstract
The antiviral activity of interferon-lambda (IFN-lambda) against several viruses has been reported, but it has not been investigated whether human IFN-lambda can affect replication of the hepatitis B virus (HBV) in human hepatocyte-derived cells. We found that replication of HBV in a human hepatoma cell line was reduced by approximately 30% following treatment with a high concentration of IFN-lambda. Furthermore, we showed that replication of HBV in another human hepatoma cell line was not suppressed by IFN-lambda. However, these cell lines showed a similar level of transcription for the heterodimeric IFN-lambda receptor and the IFN-lambda-induced antiviral proteins. Our results suggest that the antiviral activity of IFN-lambda against HBV may be limited in human cells.Entities:
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Year: 2007 PMID： 17451832 DOI： 10.1016/j.virusres.2007.03.006
Source DB: PubMed Journal: Virus Res ISSN： 0168-1702 Impact factor: 3.303