| Literature DB >> 17451451 |
L K Heisler1, L Zhou, P Bajwa, J Hsu, L H Tecott.
Abstract
Central serotonin (5-hydroxytryptamine, 5-HT) systems have been implicated in the pathophysiology and treatment of anxiety disorders, which are among the world's most prevalent psychiatric conditions. Here, we report that the 5-HT(2C) receptor (5-HT(2C)R) subtype is critically involved in regulating behaviors characteristic of anxiety using male 5-HT(2C)R knockout (KO) mice. Specific neural substrates underlying the 5-HT(2C)R KO anxiolytic phenotype were investigated, and we report that 5-HT(2C)R KO mice display a selective blunting of extended amygdala corticotropin-releasing hormone neuronal activation in response to anxiety stimuli. These findings illustrate a mechanism through which 5-HT(2C)Rs affect anxiety-related behavior and provide insight into the neural circuitry mediating the complex psychological process of anxiety.Entities:
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Year: 2007 PMID： 17451451 DOI： 10.1111/j.1601-183X.2007.00316.x
Source DB: PubMed Journal: Genes Brain Behav ISSN： 1601-183X Impact factor: 3.449