Literature DB >> 17449246

Technetium-99m-labeling and synthesis of thymidine analogs: potential candidates for tumor imaging.

Bao Teng1, Yunpeng Bai, Yu Chang, Shizhen Chen, Zhaolong Li.   

Abstract

The technetium-99m-labeling and synthesis of a series of thymidine analogs were studied. The target molecules were obtained by using 6-hydrazinopyridine-3-carboxylic acid (HYNIC) as a bifunctional coupling agent and using N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine (tricine) and ethylenediamine-N,N'-diacetic acid (EDDA) as coligands. The effects of different spacers between thymidine analog with HYNIC on radiochemical yield were also studied.

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Year:  2007        PMID: 17449246     DOI: 10.1016/j.bmcl.2007.03.086

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  4 in total

1.  Novel 99mTc-labelled complexes with thymidine isocyanide: radiosynthesis and evaluation as potential tumor imaging tracers.

Authors:  Xiaojiang Duan; Xuran Zhang; Qianqian Gan; Si'an Fang; Qing Ruan; Xiaoqing Song; Junbo Zhang
Journal:  Medchemcomm       Date:  2018-03-06       Impact factor: 3.597

2.  Single-step conjugation of bioactive peptides to proteins via a self-contained succinimidyl bis-arylhydrazone.

Authors:  Joy A Phillips; Edward L Morgan; Yuxiang Dong; Garry T Cole; Cody McMahan; Chiung-Yu Hung; Sam D Sanderson
Journal:  Bioconjug Chem       Date:  2009-09-29       Impact factor: 4.774

3.  Preparation and preliminary biological evaluation of novel (99m)Tc-labelled thymidine analogs as tumor imaging agents.

Authors:  Chunxiong Lu; Quanfu Jiang; Cheng Tan; Jie Tang; Jiankang Zhang
Journal:  Molecules       Date:  2012-07-16       Impact factor: 4.411

4.  Rhenium and Technetium-oxo Complexes with Thioamide Derivatives of Pyridylhydrazine Bifunctional Chelators Conjugated to the Tumour Targeting Peptides Octreotate and Cyclic-RGDfK.

Authors:  Andrea J North; John A Karas; Michelle T Ma; Philip J Blower; Uwe Ackermann; Jonathan M White; Paul S Donnelly
Journal:  Inorg Chem       Date:  2017-08-02       Impact factor: 5.165

  4 in total

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