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Literature DB >> 17448985

Targeting the sticky fingers of HIV-1.

Abstract

Although human blood plasma contains molecules that inhibit the activity of HIV-1, their identity is largely unknown. Münch et al. (2007) now identify a peptide corresponding to a portion of alpha1-antitrypsin that potently inhibits entry of HIV-1 into host cells by binding to a hydrophobic segment of the viral envelope glycoprotein gp41.

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Year: 2007 PMID： 17448985 DOI： 10.1016/j.cell.2007.04.005

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

10 in total

1. The SCHOOL of nature: III. From mechanistic understanding to novel therapies.

Authors: Alexander B Sigalov
Journal: Self Nonself Date: 2010-06-11

2. Identification of a gp41 core-binding molecule with homologous sequence of human TNNI3K-like protein as a novel human immunodeficiency virus type 1 entry inhibitor.

Authors: Yun Zhu; Lu Lu; Liling Xu; Hengwen Yang; Shibo Jiang; Ying-Hua Chen
Journal: J Virol Date: 2010-06-30 Impact factor: 5.103

3. Reduced Susceptibility to VIRIP-Based HIV-1 Entry Inhibitors Has a High Genetic Barrier and Severe Fitness Costs.

Authors: Janis A Müller; Anna Glöckle; Ali Gawanbacht; Matthias Geyer; Jan Münch; Frank Kirchhoff
Journal: J Virol Date: 2018-08-16 Impact factor: 5.103

4. HIV-1 gp41 transmembrane domain interacts with the fusion peptide: implication in lipid mixing and inhibition of virus-cell fusion.

Authors: Eliran Moshe Reuven; Yakir Dadon; Mathias Viard; Nurit Manukovsky; Robert Blumenthal; Yechiel Shai
Journal: Biochemistry Date: 2012-03-23 Impact factor: 3.162

5. Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection.

Authors: Holger B Kramer; Kerry J Lavender; Li Qin; Andrea R Stacey; Michael K P Liu; Katalin di Gleria; Alison Simmons; Nancy Gasper-Smith; Barton F Haynes; Andrew J McMichael; Persephone Borrow; Benedikt M Kessler
Journal: PLoS Pathog Date: 2010-05-06 Impact factor: 6.823

6. Photoinduced reactivity of the HIV-1 envelope glycoprotein with a membrane-embedded probe reveals insertion of portions of the HIV-1 Gp41 cytoplasmic tail into the viral membrane.

Authors: Mathias Viard; Sherimay D Ablan; Ming Zhou; Timothy D Veenstra; Eric O Freed; Yossef Raviv; Robert Blumenthal
Journal: Biochemistry Date: 2008-01-17 Impact factor: 3.162

Targeting the sticky fingers of HIV-1.

1. The SCHOOL of nature: III. From mechanistic understanding to novel therapies.

2. Identification of a gp41 core-binding molecule with homologous sequence of human TNNI3K-like protein as a novel human immunodeficiency virus type 1 entry inhibitor.

3. Reduced Susceptibility to VIRIP-Based HIV-1 Entry Inhibitors Has a High Genetic Barrier and Severe Fitness Costs.

4. HIV-1 gp41 transmembrane domain interacts with the fusion peptide: implication in lipid mixing and inhibition of virus-cell fusion.

5. Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection.

6. Photoinduced reactivity of the HIV-1 envelope glycoprotein with a membrane-embedded probe reveals insertion of portions of the HIV-1 Gp41 cytoplasmic tail into the viral membrane.

Review 7. Discovery of modulators of HIV-1 infection from the human peptidome.

Review 8. The three lives of viral fusion peptides.

Review 9. SCHOOL model and new targeting strategies.

Review 10. Interfacial pre-transmembrane domains in viral proteins promoting membrane fusion and fission.