OBJECTIVES: To present the classifications of malignant ameloblastomas, provide histopathologic guidelines for the diagnosis of ameloblastic carcinoma, and discuss treatment and long-term follow-up. STUDY DESIGN: Fourteen archival specimens of ameloblastic carcinoma with detailed treatment and follow-up documentation were identified by the authors. RESULTS: Traditional methods of microscopic observation form the basis for diagnosis. Histopathologic features of ameloblastic carcinoma include lack of differentiation, hypercellularity, high mitotic index, vascular invasion, and neural invasion. CONCLUSION: The long-term follow-up findings in this study support the concept that aggressive surgical intervention provides the best chance for survival. Patients treated otherwise had recurrence. The patients with the highest number of recurrences did not survive the disease.
OBJECTIVES: To present the classifications of malignant ameloblastomas, provide histopathologic guidelines for the diagnosis of ameloblastic carcinoma, and discuss treatment and long-term follow-up. STUDY DESIGN: Fourteen archival specimens of ameloblastic carcinoma with detailed treatment and follow-up documentation were identified by the authors. RESULTS: Traditional methods of microscopic observation form the basis for diagnosis. Histopathologic features of ameloblastic carcinoma include lack of differentiation, hypercellularity, high mitotic index, vascular invasion, and neural invasion. CONCLUSION: The long-term follow-up findings in this study support the concept that aggressive surgical intervention provides the best chance for survival. Patients treated otherwise had recurrence. The patients with the highest number of recurrences did not survive the disease.
Authors: Andrew C McClary; Robert B West; Ashley C McClary; Jonathan R Pollack; Nancy J Fischbein; Christopher F Holsinger; John Sunwoo; A Dimitrios Colevas; Davud Sirjani Journal: Eur Arch Otorhinolaryngol Date: 2015-04-30 Impact factor: 2.503
Authors: Alexandra D Jensen; Swantje Ecker; Malte Ellerbrock; Anna Nikoghosyan; Jürgen Debus; Marc W Münter Journal: Radiat Oncol Date: 2011-02-06 Impact factor: 3.481
Authors: Ivana D Petrovic; Jocelyn Migliacci; Ian Ganly; Snehal Patel; Bin Xu; Ronald Ghossein; Joseph Huryn; Jatin Shah Journal: Ear Nose Throat J Date: 2018-07 Impact factor: 1.697
Authors: Diurianne Caroline Campos França; João Milanez Moreira; Sandra Maria Herondina Coelho Ávila DE Aguiar; Artur Aburad DE Carvalhos; Marcelo Coelho Goiato Journal: Oncol Lett Date: 2012-09-25 Impact factor: 2.967