PURPOSE: We examined the association between endometriosis and exposure to polybrominated biphenyls (PBBs) and polychlorinated biphenyls (PCBs) among women inadvertently exposed to PBBs in 1973. METHODS: Serum PBBs and PCBs were measured in the late 1970s. Women self-reported endometriosis at interview in 1997. We constructed Cox models to estimate the relative incidence of endometriosis in relation to PBB and PCB levels. RESULTS: Seventy-nine of 943 women (9%) reported endometriosis. Compared with women with low PBB exposure (<or=1 parts per billion [ppb]), women with moderate PBB (1-4 ppb) (hazard ratio [HR] = 0.72; 95% confidence interval [CI], 0.39-1.31) and high PBB (>or=4 ppb) (HR = 0.90; 95% CI, 0.51-1.59) exposure did not have increased incidence of endometriosis. Increased incidence of endometriosis was suggested among women exposed to moderate PCB (5-8 ppb) (HR = 1.67; 95% CI, 0.91-3.10) and high PCB (>or=8 ppb) (HR = 1.68; 95% CI, 0.95-2.98) levels compared with low PCB exposure (<or=5 ppb). CONCLUSIONS: Our study does not support an association between PBB exposure and endometriosis. Findings for serum PCB level are consistent with an emerging body of literature suggesting an association between PCB exposure and endometriosis.
PURPOSE: We examined the association between endometriosis and exposure to polybrominated biphenyls (PBBs) and polychlorinated biphenyls (PCBs) among women inadvertently exposed to PBBs in 1973. METHODS: Serum PBBs and PCBs were measured in the late 1970s. Women self-reported endometriosis at interview in 1997. We constructed Cox models to estimate the relative incidence of endometriosis in relation to PBB and PCB levels. RESULTS: Seventy-nine of 943 women (9%) reported endometriosis. Compared with women with low PBB exposure (<or=1 parts per billion [ppb]), women with moderate PBB (1-4 ppb) (hazard ratio [HR] = 0.72; 95% confidence interval [CI], 0.39-1.31) and high PBB (>or=4 ppb) (HR = 0.90; 95% CI, 0.51-1.59) exposure did not have increased incidence of endometriosis. Increased incidence of endometriosis was suggested among women exposed to moderate PCB (5-8 ppb) (HR = 1.67; 95% CI, 0.91-3.10) and high PCB (>or=8 ppb) (HR = 1.68; 95% CI, 0.95-2.98) levels compared with low PCB exposure (<or=5 ppb). CONCLUSIONS: Our study does not support an association between PBB exposure and endometriosis. Findings for serum PCB level are consistent with an emerging body of literature suggesting an association between PCB exposure and endometriosis.
Authors: H M Blanck; M Marcus; P E Tolbert; C Rubin; A K Henderson; V S Hertzberg; R H Zhang; L Cameron Journal: Epidemiology Date: 2000-11 Impact factor: 4.822
Authors: Reinhard Kaiser; Michele Marcus; Heidi Michels Blanck; Mary Naughton; Rebecca H Zhang; Alden K Henderson; Paige E Tolbert; Carol H Rubin; Vicki S Hertzberg Journal: Ann Epidemiol Date: 2003-01 Impact factor: 3.797
Authors: A R Thomas; M Marcus; R H Zhang; H M Blanck; P E Tolbert; V Hertzberg; A K Henderson; C Rubin Journal: Environ Health Perspect Date: 2001-11 Impact factor: 9.031
Authors: Brenda Eskenazi; Paolo Mocarelli; Marcella Warner; Steven Samuels; Paolo Vercellini; David Olive; Larry L Needham; Donald G Patterson; Paolo Brambilla; Nicoletta Gavoni; Stefania Casalini; Stefania Panazza; Wayman Turner; Pier Mario Gerthoux Journal: Environ Health Perspect Date: 2002-07 Impact factor: 9.031
Authors: Sabrina A Gerkowicz; Sarah W Curtis; Anna K Knight; Dawayland O Cobb; Jessica B Spencer; Karen N Conneely; Metrecia L Terrell; Michele Marcus; Alica K Smith Journal: J Assist Reprod Genet Date: 2020-02-05 Impact factor: 3.412
Authors: Germaine M Buck Louis; C Matthew Peterson; Zhen Chen; Mary L Hediger; Mary S Croughan; Rajeshwari Sundaram; Joseph B Stanford; Victor Y Fujimoto; Michael W Varner; Linda C Giudice; Anne Kennedy; Liping Sun; Qian Wu; Kurunthachalam Kannan Journal: Epidemiology Date: 2012-11 Impact factor: 4.822
Authors: Denise J Jamieson; Metrecia L Terrell; Nnenna N Aguocha; Chanley M Small; Lorraine L Cameron; Michele Marcus Journal: J Womens Health (Larchmt) Date: 2011-07-28 Impact factor: 2.681
Authors: D Andrew Crain; Sarah J Janssen; Thea M Edwards; Jerrold Heindel; Shuk-mei Ho; Patricia Hunt; Taisen Iguchi; Anders Juul; John A McLachlan; Jackie Schwartz; Niels Skakkebaek; Ana M Soto; Shanna Swan; Cheryl Walker; Teresa K Woodruff; Tracey J Woodruff; Linda C Giudice; Louis J Guillette Journal: Fertil Steril Date: 2008-10 Impact factor: 7.329
Authors: Sarah W Curtis; Karen N Conneely; Mary E Marder; Metrecia L Terrell; Michele Marcus; Alicia K Smith Journal: Epigenomics Date: 2018-06-11 Impact factor: 4.778
Authors: Maria Grazia Porpora; Emanuela Medda; Annalisa Abballe; Simone Bolli; Isabella De Angelis; Alessandro di Domenico; Annamaria Ferro; Anna Maria Ingelido; Antonella Maggi; Pierluigi Benedetti Panici; Elena De Felip Journal: Environ Health Perspect Date: 2009-03-31 Impact factor: 9.031
Authors: Metrecia L Terrell; Alissa K Berzen; Chanley M Small; Lorraine L Cameron; Julie J Wirth; Michele Marcus Journal: Environ Health Date: 2009-08-15 Impact factor: 5.984