| Literature DB >> 17448659 |
Fabrice Balavoine1, Patrice Malabre, Thierry Alleaume, Astrid Rey, Valérie Cherfils, Olivier Jeanneton, Sophie Seigneurin-Venin, Frédéric Revah.
Abstract
We report here new chemical series acting as antagonists of melanin-concentrating hormone receptor 1 (MCHR-1). Synthesis and structure-activity relationships are described leading to the identification of compounds with optimized in vitro pharmacological and in vitro ADME profiles. In vivo activity has been demonstrated in animal models of food intake and depression.Entities:
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Year: 2007 PMID： 17448659 DOI： 10.1016/j.bmcl.2007.04.012
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823