| Literature DB >> 17448573 |
Lúcia Fernanda C da Costa Leite1, Rosa Helena Veras Mourão, Maria do Carmo Alves de Lima, Suely Lins Galdino, Marcelo Zaldini Hernandes, Francisco de Assis Rocha Neves, Stéphanie Vidal, Jacques Barbe, Ivan da Rocha Pitta.
Abstract
New arylidene-thiazolidinediones (ATZDs) were synthesized and evaluated in the alloxan-induced hyperglycemia mice model. The molecular target taken into consideration is the nuclear PPAR-gamma whose crystallographic structure is available on the PDB database as 2PRG. Thus the hypoglycemic and hypolipidemic activities of compounds were compared with the result of their docking after removal of the co-crystallized ligand present in the 2PRG structure. Molecular modeling studies were carried out using the Autodock 3.0.5 and ADT 1.1 programs.Entities:
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Year: 2007 PMID： 17448573 DOI： 10.1016/j.ejmech.2007.02.015
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514