BACKGROUND: A 65-year-old woman with a history of liver and kidney transplantation presented with a pruritic and tender rash of 2-year duration on her left knee. METHODS: The patient had a physical examination, and multiple skin biopsies were performed. RESULTS: Examination showed a cluster of dome-shaped, violaceous papules. A skin biopsy specimen showed multiple granules containing basophilic material within the superficial to mid dermis. The grains were embedded in an eosinophilic substance and surrounded by granulomatous inflammation. A Gomori methenamine silver stain showed abundant septate hyphae, and cultures grew colonies of Microsporum canis. A diagnosis of dermatophytic granuloma, or pseudomycetoma, was made. After considering the patient's immune status, a prolonged course of fluconazole was initiated. CONCLUSION: Microsporum canis, a frequently encountered zoophilic dermatophyte associated with tinea capitis and tinea corporis, is rarely associated with a mycetoma-like presentation, grain formation, or systemic infection. The medical literature describes only six cases of M. canis causing mycetoma-like formations in immunocompromised and immunocompetent patients. This case report describes an unusual presentation of a common dermatophyte infection, and the literature review summarizes the importance of recognizing atypical presentations of dermatophyte infections. Such infections may warrant more aggressive treatment in immunocompromised patients.
BACKGROUND: A 65-year-old woman with a history of liver and kidney transplantation presented with a pruritic and tender rash of 2-year duration on her left knee. METHODS: The patient had a physical examination, and multiple skin biopsies were performed. RESULTS: Examination showed a cluster of dome-shaped, violaceous papules. A skin biopsy specimen showed multiple granules containing basophilic material within the superficial to mid dermis. The grains were embedded in an eosinophilic substance and surrounded by granulomatous inflammation. A Gomori methenamine silver stain showed abundant septate hyphae, and cultures grew colonies of Microsporum canis. A diagnosis of dermatophytic granuloma, or pseudomycetoma, was made. After considering the patient's immune status, a prolonged course of fluconazole was initiated. CONCLUSION:Microsporum canis, a frequently encountered zoophilic dermatophyte associated with tinea capitis and tinea corporis, is rarely associated with a mycetoma-like presentation, grain formation, or systemic infection. The medical literature describes only six cases of M. canis causing mycetoma-like formations in immunocompromised and immunocompetent patients. This case report describes an unusual presentation of a common dermatophyte infection, and the literature review summarizes the importance of recognizing atypical presentations of dermatophyte infections. Such infections may warrant more aggressive treatment in immunocompromised patients.