BACKGROUND: Although it is known that a given level of strain does not induce a corresponding CHD risk in all individuals, factors that predict groups at risk have remained unclear. Neuregulin-1 (NRG-1) has various roles in the development and function of the heart and autonomic nervous system. PURPOSE: We examined whether polymorphic variation in NRG-1 moderates the association between job strain and early atherosclerosis. METHODS: The participants (M age = 32.5) were 349 women and 357 men derived from the population-based Cardiovascular Risk in Young Finns study. Job strain was defined as the joint effect of job demands and job control. Preclinical atherosclerosis was measured using carotid intima-media thickness (IMT) ultrasound. RESULTS: NRG-1 single nucleotide polymorphism SNP8NRG221533 (T to C) was found to moderate the association between job strain and IMT in men (p = .04). Job strain was significantly associated with increased IMT among men with T/T genotype but not among the others. A direct association between NRG-1 and IMT was found in women. CONCLUSIONS: Our results suggest that the effect of job strain on early atherosclerosis is dependent on NRG-1 genotype in men. Gene x Environment Interaction approach seems to offer important additional information in stress research.
BACKGROUND: Although it is known that a given level of strain does not induce a corresponding CHD risk in all individuals, factors that predict groups at risk have remained unclear. Neuregulin-1 (NRG-1) has various roles in the development and function of the heart and autonomic nervous system. PURPOSE: We examined whether polymorphic variation in NRG-1 moderates the association between job strain and early atherosclerosis. METHODS: The participants (M age = 32.5) were 349 women and 357 men derived from the population-based Cardiovascular Risk in Young Finns study. Job strain was defined as the joint effect of job demands and job control. Preclinical atherosclerosis was measured using carotid intima-media thickness (IMT) ultrasound. RESULTS:NRG-1 single nucleotide polymorphism SNP8NRG221533 (T to C) was found to moderate the association between job strain and IMT in men (p = .04). Job strain was significantly associated with increased IMT among men with T/T genotype but not among the others. A direct association between NRG-1 and IMT was found in women. CONCLUSIONS: Our results suggest that the effect of job strain on early atherosclerosis is dependent on NRG-1 genotype in men. Gene x Environment Interaction approach seems to offer important additional information in stress research.
Authors: Ketan Marballi; Marlon P Quinones; Fabio Jimenez; Michael A Escamilla; Henriette Raventós; Maria Clara Soto-Bernardini; Seema S Ahuja; Consuelo Walss-Bass Journal: J Mol Med (Berl) Date: 2010-07-13 Impact factor: 4.599
Authors: Susan K Roepke; Matthew Allison; Roland Von Känel; Brent T Mausbach; Elizabeth A Chattillion; Alexandrea L Harmell; Thomas L Patterson; Joel E Dimsdale; Paul J Mills; Michael G Ziegler; Sonia Ancoli-Israel; Igor Grant Journal: Stress Date: 2011-07-26 Impact factor: 3.493
Authors: Tariq W Chohan; An Nguyen; Stephanie M Todd; Maxwell R Bennett; Paul Callaghan; Jonathon C Arnold Journal: Front Behav Neurosci Date: 2014-09-29 Impact factor: 3.558