OBJECTIVE: To evaluate hepatitis B serological markers in pregnant women from various geographical sites in Kenya. DESIGN: A cross-sectional observational study of women attending antenatal clinics. SETTING: The Kenyatta National Hospital and eight hospitals from five provinces in Kenya. SUBJECTS: All women in their third trimester of pregnancy attending the antenatal clinic over the period June 2001 to June 2002. MAIN OUTCOME MEASURES: For each pregnant woman age and gestation were documented. Hepatitis serological markers were evaluated. RESULTS: A total of 2241 pregnant women were enrolled. Among them 205 women (9.3%) were positive for HbsAg and from these 18 (8.8%) were found to have HbeAg. Protective antibodies (anti-HbsAg) were detected in 669 (30.2%) of the women. There were notable significant regional differences for HbsAg rates. CONCLUSIONS: These results confirm the presence of high disease carrier rate and the corresponding previously reported low level of HbeAg suggesting questionable low rate of perinatal transmission but high rate of horizontal transmission.
OBJECTIVE: To evaluate hepatitis B serological markers in pregnant women from various geographical sites in Kenya. DESIGN: A cross-sectional observational study of women attending antenatal clinics. SETTING: The Kenyatta National Hospital and eight hospitals from five provinces in Kenya. SUBJECTS: All women in their third trimester of pregnancy attending the antenatal clinic over the period June 2001 to June 2002. MAIN OUTCOME MEASURES: For each pregnant woman age and gestation were documented. Hepatitis serological markers were evaluated. RESULTS: A total of 2241 pregnant women were enrolled. Among them 205 women (9.3%) were positive for HbsAg and from these 18 (8.8%) were found to have HbeAg. Protective antibodies (anti-HbsAg) were detected in 669 (30.2%) of the women. There were notable significant regional differences for HbsAg rates. CONCLUSIONS: These results confirm the presence of high disease carrier rate and the corresponding previously reported low level of HbeAg suggesting questionable low rate of perinatal transmission but high rate of horizontal transmission.
Authors: Jean Jacques N Noubiap; Jobert Richie N Nansseu; Shalom Tchokfe Ndoula; Jean Joel R Bigna; Ahmadou M Jingi; Joël Fokom-Domgue Journal: BMC Public Health Date: 2015-05-02 Impact factor: 3.295
Authors: Indu Malhotra; Maxim McKibben; Peter Mungai; Elisabeth McKibben; Xuelei Wang; Laura J Sutherland; Eric M Muchiri; Charles H King; Christopher L King; A Desiree LaBeaud Journal: PLoS Negl Trop Dis Date: 2015-01-15
Authors: Prasad Palani Velu; Courtney A Gravett; Tom K Roberts; Thor A Wagner; Jian Shayne F Zhang; Craig E Rubens; Michael G Gravett; Harry Campbell; Igor Rudan Journal: J Glob Health Date: 2011-12 Impact factor: 4.413
Authors: Nelson J Fomulu; Frederick L I Morfaw; Judith N Torimiro; Philip Nana; Mve V Koh; Takang William Journal: BMC Pregnancy Childbirth Date: 2013-08-08 Impact factor: 3.007