| Literature DB >> 17446476 |
Michael Reppel1, Bernd K Fleischmann, Hannes Reuter, Frank Pillekamp, Heribert Schunkert, Jürgen Hescheler.
Abstract
Cardiac NCX is modulated by diverse regulatory elements. Although there is consensus about the regulatory function of Na+ and Ca2+ and other elements, for example, ATP, there is still a controversial debate about the functional role of cyclic nucleotides and protein kinases. Future studies should focus on that topic since disturbances of cAMP/cGMP concentration and kinase activity may lead to severe functional disorders in the diseased heart. S100A1 is presumably a novel regulator of NCX.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17446476 DOI： 10.1196/annals.1387.065
Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691