Literature DB >> 17446070

Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis.

Li Chen1, Yihua Zhang, Xiangwen Kong, Sixun Peng, Jide Tian.   

Abstract

A total of 106 nitric oxide-releasing derivatives of oleanolic acid were synthesized and their effects on the inhibition of anti-Fas-mediated HepG2 cell apoptosis were evaluated in vitro. Several compounds inhibited anti-Fas-mediated HepG2 cell apoptosis in a dose-dependent manner. Within this series of compounds, 8b is the most potent inhibitor. The development of new NO-releasing derivatives of oleanolic acid may aid in the design of NO-based medicines for the intervention of human liver inflammatory diseases.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17446070      PMCID： PMC1986654          DOI： 10.1016/j.bmcl.2007.03.068

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  15 in total

Review 1.  Does nitric oxide modulate mitochondrial energy generation and apoptosis?

Authors:  Salvador Moncada; Jorge D Erusalimsky
Journal:  Nat Rev Mol Cell Biol       Date:  2002-03       Impact factor: 94.444

Review 2.  Current trends in the development of nitric oxide donors.

Authors:  Y C Hou; A Janczuk; P G Wang
Journal:  Curr Pharm Des       Date:  1999-06       Impact factor: 3.116

3.  Studies on the preventive action of oleanolic acid on experimental cirrhosis.

Authors:  D W Han; X H Ma; Y C Zhao; L Yin; C X Ji
Journal:  J Tradit Chin Med       Date:  1982-06       Impact factor: 0.848

4.  An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity.

Authors:  S Fiorucci; A Mencarelli; B Palazzetti; P Del Soldato; A Morelli; L J Ignarro
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-13       Impact factor: 11.205

5.  Hepatocyte damage induced by lymphocytes from patients with chronic liver diseases, as detected by LDH release.

Authors:  E Fernandez-Cruz; P Escartin; A Bootello; M Kreisler; J M Segovia de Arana
Journal:  Clin Exp Immunol       Date:  1978-03       Impact factor: 4.330

6.  Antiinflammatory effect of tetramethylpyrazine and ferulic acid.

Authors:  Y Ozaki
Journal:  Chem Pharm Bull (Tokyo)       Date:  1992-04       Impact factor: 1.645

7.  Direct evidence that induced nitric oxide production in hepatocytes prevents liver damage during lipopolysaccharide tolerance in rats.

Authors:  Yoshiaki Ebisawa; Toru Kono; Masashi Yoneda; Toshiyuki Asama; Naoyuki Chisato; Mutsubu Sugawara; Kazushi Ishikawa; Jun Iwamoto; Tokiyoshi Ayabe; Yutaka Kohgo; Shinichi Kasai
Journal:  J Surg Res       Date:  2004-05-15       Impact factor: 2.192

8.  Oleanolic acid protects against cadmium hepatotoxicity by inducing metallothionein.

Authors:  Y Liu; H Kreppel; J Liu; S Choudhuri; C D Klaassen
Journal:  J Pharmacol Exp Ther       Date:  1993-07       Impact factor: 4.030

9.  Protective effects of oleanolic acid on acetaminophen-induced hepatotoxicity in mice.

Authors:  J Liu; Y Liu; C Madhu; C D Klaassen
Journal:  J Pharmacol Exp Ther       Date:  1993-09       Impact factor: 4.030

10.  Roles of nitric oxide in tumor growth.

Authors:  D C Jenkins; I G Charles; L L Thomsen; D W Moss; L S Holmes; S A Baylis; P Rhodes; K Westmore; P C Emson; S Moncada
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-09       Impact factor: 11.205
View more
  3 in total

1.  Oleanolic acid derivatives induce apoptosis in human leukemia K562 cell involved in inhibition of both Akt1 translocation and pAkt1 expression.

Authors:  Shuhua Pan; Jun Hu; Tingting Zheng; Xinyuan Liu; Yong Ju; Chuanlian Xu
Journal:  Cytotechnology       Date:  2014-04-12       Impact factor: 2.058

2.  Matsuda-Heck reaction with arenediazonium tosylates in water.

Authors:  Ksenia V Kutonova; Marina E Trusova; Andrey V Stankevich; Pavel S Postnikov; Victor D Filimonov
Journal:  Beilstein J Org Chem       Date:  2015-03-16       Impact factor: 2.883

3.  Synthesis of hydroxycinnamic acid derivatives as mitochondria-targeted antioxidants and cytotoxic agents.

Authors:  Jiyu Li; Dian He; Baitao Wang; Ling Zhang; Kun Li; Qinjian Xie; Lifang Zheng
Journal:  Acta Pharm Sin B       Date:  2016-06-02       Impact factor: 11.413
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.