OBJECTIVE: Parental HIV infection may affect even those exposed children who remain uninfected. We investigated early growth, an indicator of overall health, of infants born to Zambian mothers recruited for a study of breastfeeding and postpartum health. METHODS: HIV-infected and uninfected women in Lusaka were followed regularly from late pregnancy to 16 weeks postpartum. Infant weight and length were measured at birth, 6 and 16 weeks. Infant HIV status could not be specifically determined in this cohort so comparisons were between all infants of HIV-uninfected mothers (n = 184) and those infants of HIV-infected mothers who were known to be alive and showed no clinical evidence of HIV infection at age 2-4 years (n = 85). RESULTS: Most infants were exclusively or predominantly breastfed until 16 weeks. At all time points infants of HIV-infected mothers tended to have lower weight and length standard deviation (Z) scores (significant for weight at 6 weeks; P = 0.04), even after adjustment for their lower gestational age at birth, compared with infants of uninfected mothers. In multivariate analyses the major factors affecting weight or length at 6 or 16 weeks of age were birth weight or length, and maternal subclinical mastitis, primiparity and weight during pregnancy. CONCLUSIONS: Early growth of infants of HIV-infected mothers is less than that of uninfected mothers, in part associated with subclinical mastitis, and this effect cannot be overcome with intensive support of mothers to follow international recommendations regarding exclusive breastfeeding.
OBJECTIVE: Parental HIV infection may affect even those exposed children who remain uninfected. We investigated early growth, an indicator of overall health, of infants born to Zambian mothers recruited for a study of breastfeeding and postpartum health. METHODS:HIV-infected and uninfected women in Lusaka were followed regularly from late pregnancy to 16 weeks postpartum. Infant weight and length were measured at birth, 6 and 16 weeks. Infant HIV status could not be specifically determined in this cohort so comparisons were between all infants of HIV-uninfected mothers (n = 184) and those infants of HIV-infected mothers who were known to be alive and showed no clinical evidence of HIV infection at age 2-4 years (n = 85). RESULTS: Most infants were exclusively or predominantly breastfed until 16 weeks. At all time points infants of HIV-infected mothers tended to have lower weight and length standard deviation (Z) scores (significant for weight at 6 weeks; P = 0.04), even after adjustment for their lower gestational age at birth, compared with infants of uninfected mothers. In multivariate analyses the major factors affecting weight or length at 6 or 16 weeks of age were birth weight or length, and maternal subclinical mastitis, primiparity and weight during pregnancy. CONCLUSIONS: Early growth of infants of HIV-infected mothers is less than that of uninfected mothers, in part associated with subclinical mastitis, and this effect cannot be overcome with intensive support of mothers to follow international recommendations regarding exclusive breastfeeding.
Authors: Charlotte E Lane; Emily A Bobrow; Diuedonne Ndatimana; Gilles F Ndayisaba; Linda S Adair Journal: Matern Child Nutr Date: 2019-01-29 Impact factor: 3.092
Authors: Anna Lartey; Grace S Marquis; Robert Mazur; Rafael Perez-Escamilla; Lucy Brakohiapa; William Ampofo; Daniel Sellen; Seth Adu-Afarwuah Journal: Matern Child Nutr Date: 2012-08-20 Impact factor: 3.092
Authors: Rachel Peletz; Michelo Simuyandi; Martin Simunyama; Kelvin Sarenje; Paul Kelly; Thomas Clasen Journal: Am J Trop Med Hyg Date: 2013-10-07 Impact factor: 2.345
Authors: Malango T Msukwa; Janne Estill; Andreas D Haas; Joep J van Oosterhout; Lyson Tenthani; Mary-Ann Davies; Kali Tal; Nozgechi Phiri; Adrian Spoerri; Bryan C Mthiko; Frank Chimbwandira; Olivia Keiser Journal: AIDS Date: 2018-09-24 Impact factor: 4.177
Authors: Christopher R Sudfeld; Quanhong Lei; Yvonne Chinyanga; Esther Tumbare; Nealia Khan; Fredrick Dapaah-Siakwan; Abia Sebaka; Jacinta Sibiya; Erik van Widenfelt; Roger L Shapiro; Joseph Makhema; Wafaie W Fawzi; Kathleen M Powis Journal: J Acquir Immune Defic Syndr Date: 2016-10-01 Impact factor: 3.731
Authors: Gloria E Otoo; Grace S Marquis; Daniel W Sellen; Donna J Chapman; Rafael Pérez-Escamilla Journal: J Hum Lact Date: 2009-10-06 Impact factor: 2.219