OBJECTIVE: In critically ill patients, a decrease in whole body oxygen consumption under hyperoxia has been reported and this could be related to hyperoxia-induced arterial changes. We investigated changes in brachial artery circulation and tone during short-term hyperoxic ventilation in septic patients. DESIGN AND SETTING: Prospective clinical study in the intensive care unit of a university hospital. PATIENTS: Fourteen patients (severe sepsis n=3 and septic shock n=11) requiring mechanically controlled ventilation due to sepsis syndrome were investigated under stable clinical conditions. INTERVENTIONS: After a 20-min period of hyperoxic ventilation (inspired oxygen fraction = 100%), two-dimensional images of brachial artery cross-sectional area and brachial blood flow velocities were recorded using conventional ultrasonography and pulsed Doppler simultaneously with invasive arterial pressure measurements. MEASUREMENTS AND MAIN RESULTS: Hyperoxia did not affect heart rate, but increased mean arterial pressure and decreased cross-sectional areas both at the end of diastole and at the end of systole. Haemodynamic study showed an increase in resistance index, and a decrease in distensibility and compliance coefficients. Furthermore, a decrease in brachial artery blood flow and arterial oxygen delivery was observed during hyperoxic exposure. CONCLUSIONS: Hyperoxia was paradoxically demonstrated to decrease oxygen delivery in upper limbs during septic shock.
OBJECTIVE: In critically illpatients, a decrease in whole body oxygen consumption under hyperoxia has been reported and this could be related to hyperoxia-induced arterial changes. We investigated changes in brachial artery circulation and tone during short-term hyperoxic ventilation in septic patients. DESIGN AND SETTING: Prospective clinical study in the intensive care unit of a university hospital. PATIENTS: Fourteen patients (severe sepsis n=3 and septic shock n=11) requiring mechanically controlled ventilation due to sepsis syndrome were investigated under stable clinical conditions. INTERVENTIONS: After a 20-min period of hyperoxic ventilation (inspired oxygen fraction = 100%), two-dimensional images of brachial artery cross-sectional area and brachial blood flow velocities were recorded using conventional ultrasonography and pulsed Doppler simultaneously with invasive arterial pressure measurements. MEASUREMENTS AND MAIN RESULTS:Hyperoxia did not affect heart rate, but increased mean arterial pressure and decreased cross-sectional areas both at the end of diastole and at the end of systole. Haemodynamic study showed an increase in resistance index, and a decrease in distensibility and compliance coefficients. Furthermore, a decrease in brachial artery blood flow and arterial oxygen delivery was observed during hyperoxic exposure. CONCLUSIONS:Hyperoxia was paradoxically demonstrated to decrease oxygen delivery in upper limbs during septic shock.
Authors: Sebastian Hafner; François Beloncle; Andreas Koch; Peter Radermacher; Pierre Asfar Journal: Ann Intensive Care Date: 2015-11-19 Impact factor: 6.925
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Authors: Bob Smit; Yvo M Smulders; Etto C Eringa; Harry P M M Gelissen; Armand R J Girbes; Harm-Jan S de Grooth; Hans H M Schotman; Peter G Scheffer; Heleen M Oudemans-van Straaten; Angelique M E Spoelstra-de Man Journal: Microcirculation Date: 2018-02 Impact factor: 2.628
Authors: Ashley Sanello; Marianne Gausche-Hill; William Mulkerin; Karl A Sporer; John F Brown; Kristi L Koenig; Eric M Rudnick; Angelo A Salvucci; Gregory H Gilbert Journal: West J Emerg Med Date: 2018-03-08