Literature DB >> 17444687

Isothiocyanates from tosyl chloride mediated decomposition of in situ generated dithiocarbamic acid salts.

Rince Wong1, Sarah J Dolman.   

Abstract

A facile and general protocol for the preparation of isothiocyanates from alkyl and aryl amines is reported. This method relies on a tosyl chloride mediated decomposition of a dithiocarbamate salt that is generated in situ by treatment of an amine with carbon disulfide and triethylamine. Utilizing this protocol, we have prepared 19-alkyl- and arylisothiocyanates in moderate to excellent yield.

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Year:  2007        PMID： 17444687     DOI： 10.1021/jo070246n

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  24 in total

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