Literature DB >> 17444626

Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and anti-inflammatory agents.

Anastasia Detsi1, Dionysia Bouloumbasi, Kyriakos C Prousis, Maria Koufaki, Giorgos Athanasellis, Georgia Melagraki, Antreas Afantitis, Olga Igglessi-Markopoulou, Christos Kontogiorgis, Dimitra J Hadjipavlou-Litina.   

Abstract

A series of N-substituted-quinolinone-3-aminoamides and their hybrids containing the alpha-lipoic acid functionality were designed and synthesized as potential bifunctional agents combining antioxidant and anti-inflammatory activity. The new compounds were evaluated for their antioxidant activity and for their ability to inhibit in vitro lipoxygenase as well as for their anti-inflammatory activity in vivo. In general, the derivatives were found to be potent antioxidant or anti-inflammatory agents. The results are discussed in terms of structure-activity relationships and an attempt is made to define the structural features required for activity.

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Year:  2007        PMID： 17444626     DOI： 10.1021/jm061173n

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  7 in total

1.  Quinoline ring derivatives protect against aminoglycoside-induced hair cell death in the zebrafish lateral line.

Authors:  Henry C Ou; Sarah Keating; Patricia Wu; Julian A Simon; David W Raible; Edwin W Rubel
Journal:  J Assoc Res Otolaryngol       Date:  2012-10-10

2.  Evaluation of xanthene-appended quinoline hybrids as potential leads against antimalarial drug targets.

Authors:  R Jesu Jaya Sudan; J Lesitha Jeeva Kumari; P Iniyavan; S Sarveswari; V Vijayakumar
Journal:  Mol Divers       Date:  2022-05-18       Impact factor: 2.943

3.  Hemoglobin-driven iron-directed assembly of gold nanoparticles.

Authors:  Jacquelyn G Egan; Nicole Drossis; Iraklii I Ebralidze; Holly M Fruehwald; Nadia O Laschuk; Jade Poisson; Hendrick W de Haan; Olena V Zenkina
Journal:  RSC Adv       Date:  2018-04-26       Impact factor: 4.036

4.  Novel quinolinone-pyrazoline hybrids: synthesis and evaluation of antioxidant and lipoxygenase inhibitory activity.

Authors:  Ioanna Kostopoulou; Antonia Diassakou; Eleni Kavetsou; Eftichia Kritsi; Panagiotis Zoumpoulakis; Eleni Pontiki; Dimitra Hadjipavlou-Litina; Anastasia Detsi
Journal:  Mol Divers       Date:  2020-02-17       Impact factor: 2.943

5.  Discovery of C-3 Tethered 2-oxo-benzo[1,4]oxazines as Potent Antioxidants: Bio-Inspired Based Design, Synthesis, Biological Evaluation, Cytotoxic, and in Silico Molecular Docking Studies.

Authors:  Vashundhra Sharma; Pradeep K Jaiswal; Mukesh Saran; Dharmendra Kumar Yadav; Manas Mathur; Ajit K Swami; Sanjeev Misra; Mi-Hyun Kim; Sandeep Chaudhary
Journal:  Front Chem       Date:  2018-03-23       Impact factor: 5.221

Review 6.  Profiling donepezil template into multipotent hybrids with antioxidant properties.

Authors:  Eva Mezeiova; Katarina Spilovska; Eugenie Nepovimova; Lukas Gorecki; Ondrej Soukup; Rafael Dolezal; David Malinak; Jana Janockova; Daniel Jun; Kamil Kuca; Jan Korabecny
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

7.  Synthesis and Biological Evaluation of Novel Isoxazole-Amide Analogues as Anticancer and Antioxidant Agents.

Authors:  Ahmad M Eid; Mohammed Hawash; Johnny Amer; Abdullah Jarrar; Samira Qadri; Iman Alnimer; Aya Sharaf; Raya Zalmoot; Osama Hammoudie; Saba Hameedi; Ahmed Mousa
Journal:  Biomed Res Int       Date:  2021-03-09       Impact factor: 3.411
  7 in total

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