Literature DB >> 17442723

Prion protein alleles showing a protective effect on the susceptibility of sheep to scrapie and bovine spongiform encephalopathy.

Gabriele Vaccari1, Claudia D'Agostino, Romolo Nonno, Francesca Rosone, Michela Conte, Michele Angelo Di Bari, Barbara Chiappini, Elena Esposito, Luigi De Grossi, Francesco Giordani, Stefano Marcon, Luisella Morelli, Renata Borroni, Umberto Agrimi.   

Abstract

The susceptibility of sheep to classical scrapie and bovine spongiform encephalopathy (BSE) is mainly influenced by prion protein (PrP) polymorphisms A136V, R154H, and Q171R, with the ARR allele associated with significantly decreased susceptibility. Here we report the protective effect of the amino acid substitution M137T, I142K, or N176K on the ARQ allele in sheep experimentally challenged with either scrapie or BSE. Such observations suggest the existence of additional PrP alleles that significantly decrease the susceptibility of sheep to transmissible spongiform encephalopathies, which may have important implications for disease eradication strategies.

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Year:  2007        PMID： 17442723      PMCID： PMC1933282          DOI： 10.1128/JVI.02880-06

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

1.  Prion diseases: BSE in sheep bred for resistance to infection.

Authors:  Fiona Houston; Wilfred Goldmann; Angela Chong; Martin Jeffrey; Lorenzo González; James Foster; David Parnham; Nora Hunter
Journal:  Nature       Date:  2003-05-29       Impact factor: 49.962

2.  Neuronal accumulation of abnormal prion protein in sheep carrying a scrapie-resistant genotype (PrPARR/ARR).

Authors:  Anne Buschmann; Gesine Lühken; Julia Schultz; G Erhardt; Martin H Groschup
Journal:  J Gen Virol       Date:  2004-09       Impact factor: 3.891

3.  Susceptibility of sheep for scrapie as assessed by in vitro conversion of nine naturally occurring variants of PrP.

Authors:  A Bossers; R de Vries; M A Smits
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

4.  PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis.

Authors:  J L Laplanche; J Chatelain; D Westaway; S Thomas; M Dussaucy; J Brugere-Picoux; J M Launay
Journal:  Genomics       Date:  1993-01       Impact factor: 5.736

5.  Prion gene sequence variation within diverse groups of U.S. sheep, beef cattle, and deer.

Authors:  Michael P Heaton; Kreg A Leymaster; Brad A Freking; Deedra A Hawk; Timothy P L Smith; John W Keele; Warren M Snelling; James M Fox; Carol G Chitko-McKown; William W Laegreid
Journal:  Mamm Genome       Date:  2003-11       Impact factor: 2.957

6.  Animal transmissible spongiform encephalopathies and genetics.

Authors:  U Agrimi; M Conte; L Morelli; M A Di Bari; G Di Guardo; C Ligios; G Antonucci; G M Aufiero; N Pozzato; F Mutinelli; R Nonno; G Vaccari
Journal:  Vet Res Commun       Date:  2003-09       Impact factor: 2.459

Review 7.  Scrapie strain variation and mutation.

Authors:  M E Bruce
Journal:  Br Med Bull       Date:  1993-10       Impact factor: 4.291

Review 8.  Scrapie and experimental BSE in sheep.

Authors:  Nora Hunter
Journal:  Br Med Bull       Date:  2003       Impact factor: 4.291

9.  Two alleles of a neural protein gene linked to scrapie in sheep.

Authors:  W Goldmann; N Hunter; J D Foster; J M Salbaum; K Beyreuther; J Hope
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

10.  Risk of scrapie in British sheep of different prion protein genotype.

Authors:  M Baylis; C Chihota; E Stevenson; W Goldmann; A Smith; K Sivam; S Tongue; M B Gravenor
Journal:  J Gen Virol       Date:  2004-09       Impact factor: 3.891
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  25 in total

1.  Scrapie resistance in ARQ sheep.

Authors:  W W Laegreid; M L Clawson; M P Heaton; B T Green; K I O'Rourke; D P Knowles
Journal:  J Virol       Date:  2008-07-16       Impact factor: 5.103

Review 2.  In vitro studies of the transmission barrier.

Authors:  Natalia Fernández-Borges; Jorge de Castro; Joaquín Castilla
Journal:  Prion       Date:  2009-10-30       Impact factor: 3.931

3.  Report of outbreaks of classical scrapie in Dorper sheep and associated prion protein gene polymorphisms in affected flocks.

Authors:  Caroline Pinto de Andrade; Eduardo Conceição de Oliveira; Juliano Souza Leal; Laura Lopes de Almeida; Luiza Amaral de Castro; Sergio Ceroni da Silva; David Driemeier
Journal:  Trop Anim Health Prod       Date:  2015-05-21       Impact factor: 1.559

4.  Genetic evidence for susceptibility and resistance against scrapie in Indian sheep.

Authors:  Sharda Choudhary; Neelam Gupta; Geetika Jethra; Digpal Singh Gour
Journal:  J Genet       Date:  2015-03       Impact factor: 1.166

5.  Genetic diversity of the prion protein gene (PRNP) coding sequence in Czech sheep and evaluation of the national breeding programme for resistance to scrapie in the Czech Republic.

Authors:  Ondrej Stepanek; Petr Horin
Journal:  J Appl Genet       Date:  2016-05-23       Impact factor: 3.240

6.  Ovine reference materials and assays for prion genetic testing.

Authors:  Michael P Heaton; Kreg A Leymaster; Theodore S Kalbfleisch; Brad A Freking; Timothy P L Smith; Michael L Clawson; William W Laegreid
Journal:  BMC Vet Res       Date:  2010-04-30       Impact factor: 2.741

7.  A new method for the characterization of strain-specific conformational stability of protease-sensitive and protease-resistant PrPSc.

Authors:  Laura Pirisinu; Michele Di Bari; Stefano Marcon; Gabriele Vaccari; Claudia D'Agostino; Paola Fazzi; Elena Esposito; Roberta Galeno; Jan Langeveld; Umberto Agrimi; Romolo Nonno
Journal:  PLoS One       Date:  2010-09-14       Impact factor: 3.240

8.  Frequencies of PrP genotypes and their implication for breeding against scrapie susceptibility in nine Pakistani sheep breeds.

Authors:  M E Babar; A Farid; B F Benkel; J Ahmad; A Nadeem; M Imran
Journal:  Mol Biol Rep       Date:  2008-02-23       Impact factor: 2.316

9.  PrPC Governs Susceptibility to Prion Strains in Bank Vole, While Other Host Factors Modulate Strain Features.

Authors:  J C Espinosa; R Nonno; M Di Bari; P Aguilar-Calvo; L Pirisinu; N Fernández-Borges; I Vanni; G Vaccari; A Marín-Moreno; P Frassanito; P Lorenzo; U Agrimi; J M Torres
Journal:  J Virol       Date:  2016-11-14       Impact factor: 5.103

Review 10.  State-of-the-art review of goat TSE in the European Union, with special emphasis on PRNP genetics and epidemiology.

Authors:  Gabriele Vaccari; Cynthia H Panagiotidis; Cristina Acin; Simone Peletto; Francis Barillet; Pierluigi Acutis; Alex Bossers; Jan Langeveld; Lucien van Keulen; Theodoros Sklaviadis; Juan J Badiola; Olivier Andreéoletti; Martin H Groschup; Umberto Agrimi; James Foster; Wilfred Goldmann
Journal:  Vet Res       Date:  2009-05-28       Impact factor: 3.683
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