| Literature DB >> 17440948 |
Gillian Hamilton1, Petra Proitsi, Luke Jehu, Angharad Morgan, Julie Williams, Michael C O'Donovan, Michael J Owen, John F Powell, Simon Lovestone.
Abstract
Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes--PPARgamma, SOS2, and PCK1--with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender. (c) 2007 Wiley-Liss, Inc.Entities:
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Year: 2007 PMID： 17440948 DOI： 10.1002/ajmg.b.30503
Source DB: PubMed Journal: Am J Med Genet B Neuropsychiatr Genet ISSN： 1552-4841 Impact factor: 3.568