| Literature DB >> 17439594 |
K Takahashi1, M Miyashita, T Nomura, H Makino, R Futami, M Kashiwabara, M Katsuta, T Tajiri.
Abstract
It is reported that surveillance of serum p53 antibody (Ab) is a useful marker in detecting esophageal squamous cell carcinoma (ESCC). But there is little reported about prognostic significance of serum p53-Ab in postoperative patients with ESCC. The aim of this study is to evaluate the significance of preoperative serum p53-Ab as a marker of early recurrence after curative resection for ESCC. Enzyme-linked immunosorvent assay (ELISA) was used to analyze serum p53-Ab before treatment in 44 patients with ESCC. Carcinoembryonic antigen (CEA) and squamous cell carcinoma antigen (SCC-Ag) were examined by immunoradiometric assay. The patients who were strongly positive and positive in serum p53-Ab were more likely to have early recurrence after curative resection than seronegative patients. There were no significant correlations between CEA, SCC-Ag positivity and early recurrence. We found that serum p53-Ab was useful to predict a risk of early recurrence after curative surgical resection for ESCC.Entities:
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Year: 2007 PMID： 17439594 DOI： 10.1111/j.1442-2050.2007.00656.x
Source DB: PubMed Journal: Dis Esophagus ISSN： 1120-8694 Impact factor: 3.429