Literature DB >> 17439124

Small-molecule inhibitors of protein geranylgeranyltransferase type I.

Sabrina Castellano1, Hannah D G Fiji, Sape S Kinderman, Masaru Watanabe, Pablo de Leon, Fuyuhiko Tamanoi, Ohyun Kwon.   

Abstract

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Year:  2007        PMID： 17439124      PMCID： PMC2543057          DOI： 10.1021/ja070274n

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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  14 in total

1.  A combinatorial approach toward the generation of ambiphilic peptide-based inhibitors of protein:geranylgeranyl transferase-1.

Authors:  Farid El Oualid; Hans van den Elst; Ingrid M Leroy; Elsbeth Pieterman; Louis H Cohen; Brigitte E A Burm; Herman S Overkleeft; Gijs A van der Marel; Mark Overhand
Journal:  J Comb Chem       Date:  2005 Sep-Oct

2.  Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways.

Authors:  Chia-Ling Gau; Juran Kato-Stankiewicz; Chen Jiang; Susie Miyamoto; Lea Guo; Fuyuhiko Tamanoi
Journal:  Mol Cancer Ther       Date:  2005-06       Impact factor: 6.261

3.  Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor.

Authors:  E C Lerner; Y Qian; A D Hamilton; S M Sebti
Journal:  J Biol Chem       Date:  1995-11-10       Impact factor: 5.157

4.  Theoretical rationale for regioselection in phosphine-catalyzed allenoate additions to acrylates, imines, and aldehydes.

Authors:  Travis Dudding; Ohyun Kwon; Evan Mercier
Journal:  Org Lett       Date:  2006-08-17       Impact factor: 6.005

Review 5.  Function and regulation of ras.

Authors:  D R Lowy; B M Willumsen
Journal:  Annu Rev Biochem       Date:  1993       Impact factor: 23.643

6.  Phosphine-catalyzed synthesis of 1,3-dioxan-4-ylidenes.

Authors:  Xue-Feng Zhu; Christopher E Henry; Jay Wang; Travis Dudding; Ohyun Kwon
Journal:  Org Lett       Date:  2005-03-31       Impact factor: 6.005

7.  All ras proteins are polyisoprenylated but only some are palmitoylated.

Authors:  J F Hancock; A I Magee; J E Childs; C J Marshall
Journal:  Cell       Date:  1989-06-30       Impact factor: 41.582

8.  Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

Authors:  G L James; J L Goldstein; M S Brown
Journal:  J Biol Chem       Date:  1995-03-17       Impact factor: 5.157

9.  An expedient phosphine-catalyzed [4 + 2] annulation: synthesis of highly functionalized tetrahydropyridines.

Authors:  Xue-Feng Zhu; Jie Lan; Ohyun Kwon
Journal:  J Am Chem Soc       Date:  2003-04-23       Impact factor: 15.419

Review 10.  Farnesyl transferase inhibitors: the next targeted therapies for breast cancer?

Authors:  R M O'Regan; F R Khuri
Journal:  Endocr Relat Cancer       Date:  2004-06       Impact factor: 5.678
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  43 in total

1.  Phosphine-initiated general base catalysis: facile access to benzannulated 1,3-diheteroatom five-membered rings via double-Michael reactions of allenes.

Authors:  Judy Szeto; Vardhineedi Sriramurthy; Ohyun Kwon
Journal:  Org Lett       Date:  2011-09-20       Impact factor: 6.005

2.  Phosphine-catalyzed β'-umpolung addition of nucleophiles to activated α-alkyl allenes.

Authors:  Tioga J Martin; Venus G Vakhshori; Yang S Tran; Ohyun Kwon
Journal:  Org Lett       Date:  2011-04-14       Impact factor: 6.005

3.  Phosphine-catalyzed [4 + 2] annulation: synthesis of cyclohexenes.

Authors:  Yang S Tran; Ohyun Kwon
Journal:  J Am Chem Soc       Date:  2007-10-03       Impact factor: 15.419

4.  Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs.

Authors:  Michelle Maynor; Sarah A Scott; Emily L Rickert; Richard A Gibbs
Journal:  Bioorg Med Chem Lett       Date:  2008-02-12       Impact factor: 2.823

5.  Phosphine-catalyzed annulations of azomethine imines: allene-dependent [3 + 2], [3 + 3], [4 + 3], and [3 + 2 + 3] pathways.

Authors:  Risong Na; Chengfeng Jing; Qihai Xu; Hui Jiang; Xi Wu; Jiayan Shi; Jiangchun Zhong; Min Wang; Diego Benitez; Ekaterina Tkatchouk; William A Goddard; Hongchao Guo; Ohyun Kwon
Journal:  J Am Chem Soc       Date:  2011-08-03       Impact factor: 15.419

6.  Bisphosphine-catalyzed mixed double-Michael reactions: asymmetric synthesis of oxazolidines, thiazolidines, and pyrrolidines.

Authors:  Vardhineedi Sriramurthy; Gregg A Barcan; Ohyun Kwon
Journal:  J Am Chem Soc       Date:  2007-10-09       Impact factor: 15.419

7.  Aplexone targets the HMG-CoA reductase pathway and differentially regulates arteriovenous angiogenesis.

Authors:  Jayoung Choi; Kevin Mouillesseaux; Zhiming Wang; Hannah D G Fiji; Sape S Kinderman; Georg W Otto; Robert Geisler; Ohyun Kwon; Jau-Nian Chen
Journal:  Development       Date:  2011-02-09       Impact factor: 6.868

8.  Annulations of enantioenriched allenylsilanes with in situ generated iminium ions: stereoselective synthesis of diverse heterocycles.

Authors:  Ryan A Brawn; James S Panek
Journal:  Org Lett       Date:  2009-01-15       Impact factor: 6.005

9.  PHOSPHINE-CATALYZED [3 + 2] ANNULATION: SYNTHESIS OF ETHYL 5-(tert-BUTYL)-2-PHENYL-1-TOSYL-3-PYRROLINE-3-CARBOXYLATE.

Authors:  Ian P Andrews; Ohyun Kwon
Journal:  Organic Synth       Date:  2012

10.  Theory-Guided Design of Brønsted Acid-Assisted Phosphine Catalysis: Synthesis of Dihydropyrones from Aldehydes and Allenoates.

Authors:  Gardner S Creech; Xue-Feng Zhu; Branden Fonovic; Travis Dudding; Ohyun Kwon
Journal:  Tetrahedron       Date:  2008-07-14       Impact factor: 2.457
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