Literature DB >> 17438375

The role of angiopoietin 2 in hyperoxia-induced acute lung injury.

Vineet Bhandari1, Jack A Elias.   

Abstract

Hyperoxia-induced acute lung injury (HALI) is characterized by an influx of inflammatory cells, increased pulmonary permeability, endothelial and epithelial cell death. In a murine model and in vitro, we found Angiopoietin 2 to be a critical mediator of lung oxidant injury, inflammation, edema, and regulator of necrotic cell death pathways. The clinical significance of our findings was highlighted by the detection of increased Angiopoietin 2 levels in patients with ALI.

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Year:  2007        PMID： 17438375     DOI： 10.4161/cc.6.9.4229

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  13 in total

1.  PKR-dependent CHOP induction limits hyperoxia-induced lung injury.

Authors:  Tricia I Lozon; Alison J Eastman; Gustavo Matute-Bello; Peter Chen; Teal S Hallstrand; William A Altemeier
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2010-12-24       Impact factor: 5.464

Review 2.  The Angiopoietin-Tie2 Signaling Axis in Systemic Inflammation.

Authors:  Samir M Parikh
Journal:  J Am Soc Nephrol       Date:  2017-05-02       Impact factor: 10.121

3.  Human umbilical cord mesenchymal stem cell exosomes enhance angiogenesis through the Wnt4/β-catenin pathway.

Authors:  Bin Zhang; Xiaodan Wu; Xu Zhang; Yaoxiang Sun; Yongmin Yan; Hui Shi; Yanhua Zhu; Lijun Wu; Zhaoji Pan; Wei Zhu; Hui Qian; Wenrong Xu
Journal:  Stem Cells Transl Med       Date:  2015-03-30       Impact factor: 6.940

4.  Decreased VEGF expression and microvascular density, but increased HIF-1 and 2α accumulation and EPO expression in chronic moderate hyperoxia in the mouse brain.

Authors:  Girriso F Benderro; Xiaoyan Sun; Youzhi Kuang; Joseph C Lamanna
Journal:  Brain Res       Date:  2012-07-20       Impact factor: 3.252

5.  HIF-1α/COX-2 expression and mouse brain capillary remodeling during prolonged moderate hypoxia and subsequent re-oxygenation.

Authors:  Girriso F Benderro; Joseph C LaManna
Journal:  Brain Res       Date:  2014-05-02       Impact factor: 3.252

Review 6.  Targeting the ANGPT-TIE2 pathway in malignancy.

Authors:  Hanhua Huang; Abhijit Bhat; Gary Woodnutt; Rodney Lappe
Journal:  Nat Rev Cancer       Date:  2010-08       Impact factor: 60.716

7.  ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.

Authors:  Nuala J Meyer; Mingyao Li; Rui Feng; Jonathan Bradfield; Robert Gallop; Scarlett Bellamy; Barry D Fuchs; Paul N Lanken; Steven M Albelda; Melanie Rushefski; Richard Aplenc; Helen Abramova; Elena N Atochina-Vasserman; Michael F Beers; Carolyn S Calfee; Mitchell J Cohen; Jean-Francois Pittet; David C Christiani; Grant E O'Keefe; Lorraine B Ware; Addison K May; Mark M Wurfel; Hakon Hakonarson; Jason D Christie
Journal:  Am J Respir Crit Care Med       Date:  2011-01-21       Impact factor: 21.405

8.  Angiopoietin Level Trajectories in Toddlers With Severe Sepsis and Septic Shock and Their Effect on Capillary Endothelium.

Authors:  Richard W Pierce; Veronika Shabanova; Michael Canarie; Mathew Pinto; Yong Sing da Silva; Vineet Bhandari; John S Giuliano
Journal:  Shock       Date:  2019-03       Impact factor: 3.454

9.  TREM-1 Attenuates RIPK3-mediated Necroptosis in Hyperoxia-induced Lung Injury in Neonatal Mice.

Authors:  Mansoor Ali Syed; Dilip Shah; Pragnya Das; Sture Andersson; Gloria Pryhuber; Vineet Bhandari
Journal:  Am J Respir Cell Mol Biol       Date:  2019-03       Impact factor: 6.914

10.  LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway.

Authors:  Tadanori Mammoto; Jing Chen; Elisabeth Jiang; Amanda Jiang; Lois E Smith; Donald E Ingber; Akiko Mammoto
Journal:  PLoS One       Date:  2012-07-25       Impact factor: 3.240
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