Literature DB >> 17438053

Transient loss of high-level mupirocin resistance in Staphylococcus aureus due to MupA polymorphism.

Daniel G Driscoll1, Casey L Young, Urs A Ochsner.   

Abstract

Spontaneous loss of MupA-mediated high-level mupirocin resistance was observed in Staphylococcus aureus, although the isolate gave a PCR-positive test result for mupA. Sequencing of the mupA gene identified a single base-pair deletion that resulted in a frameshift mutation and loss of functional protein. Reversion to the wild-type allele and restoration of high-level resistance occurred with high frequency (>10(-6)), indicating the transient nature of MupA polymorphism.

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Year:  2007        PMID： 17438053      PMCID： PMC1891366          DOI： 10.1128/AAC.00241-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

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Journal:  Infect Control Hosp Epidemiol       Date:  2001-09       Impact factor: 3.254

2.  Efficacy of a new cream formulation of mupirocin: comparison with oral and topical agents in experimental skin infections.

Authors:  J Gisby; J Bryant
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4.  Emerging elevated mupirocin resistance rates among staphylococcal isolates in the SENTRY Antimicrobial Surveillance Program (2000): correlations of results from disk diffusion, Etest and reference dilution methods.

Authors:  L M Deshpande; A M Fix; M A Pfaller; R N Jones
Journal:  Diagn Microbiol Infect Dis       Date:  2002-04       Impact factor: 2.803

5.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

Authors:  J D Thompson; D G Higgins; T J Gibson
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6.  Mutations affecting the Rossman fold of isoleucyl-tRNA synthetase are correlated with low-level mupirocin resistance in Staphylococcus aureus.

Authors:  Martin Antonio; Neil McFerran; Mark J Pallen
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

7.  Interaction of pseudomonic acid A with Escherichia coli B isoleucyl-tRNA synthetase.

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Journal:  Biochem J       Date:  1980-10-01       Impact factor: 3.857

8.  Mupirocin-resistant, methicillin-resistant Staphylococcus aureus: does mupirocin remain effective?

Authors:  Elaine S Walker; Jose E Vasquez; Roy Dula; Hollie Bullock; Felix A Sarubbi
Journal:  Infect Control Hosp Epidemiol       Date:  2003-05       Impact factor: 3.254

9.  Inhibition of isoleucyl-transfer ribonucleic acid synthetase in Escherichia coli by pseudomonic acid.

Authors:  J Hughes; G Mellows
Journal:  Biochem J       Date:  1978-10-15       Impact factor: 3.857

10.  Molecular characterization of the gene encoding high-level mupirocin resistance in Staphylococcus aureus J2870.

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  7 in total

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3.  Mupirocin and chlorhexidine resistance in Staphylococcus aureus in patients with community-onset skin and soft tissue infections.

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Journal:  Antimicrob Agents Chemother       Date:  2012-11-12       Impact factor: 5.191

4.  Emergence of high-level mupirocin resistance in coagulase-negative staphylococci associated with increased short-term mupirocin use.

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5.  MupB, a new high-level mupirocin resistance mechanism in Staphylococcus aureus.

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6.  High prevalence of direct repeat unit types of 10di, 8 h and 8i among methicillin resistant Staphylococcus aureus strains with staphylococcal cassette chromosome mec type IIIA isolated in Tehran, Iran.

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Journal:  Antimicrob Resist Infect Control       Date:  2019-03-06       Impact factor: 4.887

7.  Transient Silencing of Antibiotic Resistance by Mutation Represents a Significant Potential Source of Unanticipated Therapeutic Failure.

Authors:  Louise Kime; Christopher P Randall; Frank I Banda; Francesc Coll; John Wright; Joseph Richardson; Joanna Empel; Julian Parkhill; Alex J O'Neill
Journal:  mBio       Date:  2019-10-29       Impact factor: 7.867
  7 in total

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