Literature DB >> 17438036

Inhibition of Enterococcus faecium adherence to collagen by antibodies against high-affinity binding subdomains of Acm.

Sreedhar R Nallapareddy1, Jouko Sillanpää, Vannakambadi K Ganesh, Magnus Höök, Barbara E Murray.   

Abstract

Strains of Enterococcus faecium express a cell wall-anchored protein, Acm, which mediates adherence to collagen. Here, we (i) identify the minimal and high-affinity binding subsegments of Acm and (ii) show that anti-Acm immunoglobulin Gs (IgGs) purified against these subsegments reduced E. faecium TX2535 strain collagen adherence up to 73 and 50%, respectively, significantly more than the total IgGs against the full-length Acm A domain (28%) (P < 0.0001). Blocking Acm adherence with functional subsegment-specific antibodies raises the possibility of their use as therapeutic or prophylactic agents.

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Year:  2007        PMID： 17438036      PMCID： PMC1932878          DOI： 10.1128/IAI.02016-06

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  17 in total

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2.  Construction of improved temperature-sensitive and mobilizable vectors and their use for constructing mutations in the adhesin-encoding acm gene of poorly transformable clinical Enterococcus faecium strains.

Authors:  Sreedhar R Nallapareddy; Kavindra V Singh; Barbara E Murray
Journal:  Appl Environ Microbiol       Date:  2006-01       Impact factor: 4.792

3.  A 'Collagen Hug' model for Staphylococcus aureus CNA binding to collagen.

Authors:  Yinong Zong; Yi Xu; Xiaowen Liang; Douglas R Keene; Agneta Höök; Shivasankarappa Gurusiddappa; Magnus Höök; Sthanam V L Narayana
Journal:  EMBO J       Date:  2005-12-15       Impact factor: 11.598

4.  Domain structure of the Staphylococcus aureus collagen adhesin.

Authors:  R L Rich; B Demeler; K Ashby; C C Deivanayagam; J W Petrich; J M Patti; S V Narayana; M Höök
Journal:  Biochemistry       Date:  1998-11-03       Impact factor: 3.162

5.  Structure of the collagen-binding domain from a Staphylococcus aureus adhesin.

Authors:  J Symersky; J M Patti; M Carson; K House-Pompeo; M Teale; D Moore; L Jin; A Schneider; L J DeLucas; M Höök; S V Narayana
Journal:  Nat Struct Biol       Date:  1997-10

Review 6.  MSCRAMM-mediated adherence of microorganisms to host tissues.

Authors:  J M Patti; B L Allen; M J McGavin; M Höök
Journal:  Annu Rev Microbiol       Date:  1994       Impact factor: 15.500

7.  A family of putative MSCRAMMs from Enterococcus faecalis.

Authors:  Jouko Sillanpää; Yi Xu; Sreedhar R Nallapareddy; Barbara E Murray; Magnus Höök
Journal:  Microbiology (Reading)       Date:  2004-07       Impact factor: 2.777

8.  Identification and biochemical characterization of the ligand binding domain of the collagen adhesin from Staphylococcus aureus.

Authors:  J M Patti; J O Boles; M Höök
Journal:  Biochemistry       Date:  1993-10-26       Impact factor: 3.162

9.  CNE, a collagen-binding protein of Streptococcus equi.

Authors:  Jonas Lannergård; Lars Frykberg; Bengt Guss
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10.  Streptococcus mutans strains harboring collagen-binding adhesin.

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  7 in total

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Authors:  Jouko Sillanpää; Sreedhar R Nallapareddy; Xiang Qin; Kavindra V Singh; Donna M Muzny; Christie L Kovar; Lynne V Nazareth; Richard A Gibbs; Mary J Ferraro; James M Steckelberg; George M Weinstock; Barbara E Murray
Journal:  J Bacteriol       Date:  2009-08-28       Impact factor: 3.490

2.  A functional collagen adhesin gene, acm, in clinical isolates of Enterococcus faecium correlates with the recent success of this emerging nosocomial pathogen.

Authors:  Sreedhar R Nallapareddy; Kavindra V Singh; Pablo C Okhuysen; Barbara E Murray
Journal:  Infect Immun       Date:  2008-06-30       Impact factor: 3.441

3.  Contribution of the collagen adhesin Acm to pathogenesis of Enterococcus faecium in experimental endocarditis.

Authors:  Sreedhar R Nallapareddy; Kavindra V Singh; Barbara E Murray
Journal:  Infect Immun       Date:  2008-06-30       Impact factor: 3.441

4.  Comparative genomic analysis reveals significant enrichment of mobile genetic elements and genes encoding surface structure-proteins in hospital-associated clonal complex 2 Enterococcus faecalis.

Authors:  Margrete Solheim; Mari C Brekke; Lars G Snipen; Rob J L Willems; Ingolf F Nes; Dag A Brede
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Review 5.  Polyproline and triple helix motifs in host-pathogen recognition.

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Journal:  Curr Protein Pept Sci       Date:  2012-12       Impact factor: 3.272

6.  The N-terminal domain of the thermo-regulated surface protein PrpA of Enterococcus faecium binds to fibrinogen, fibronectin and platelets.

Authors:  Ana M Guzmán Prieto; Rolf T Urbanus; Xinglin Zhang; Damien Bierschenk; C Arnold Koekman; Miranda van Luit-Asbroek; Janneke P Ouwerkerk; Marieke Pape; Fernanda L Paganelli; Dominique Wobser; Johannes Huebner; Antoni P A Hendrickx; Marc J M Bonten; Rob J L Willems; Willem van Schaik
Journal:  Sci Rep       Date:  2015-12-17       Impact factor: 4.379

Review 7.  Advances and Prospects in Vaccine Development against Enterococci.

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Journal:  Cells       Date:  2020-11-02       Impact factor: 6.600
  7 in total

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