OBJECTIVE: To evaluate abbreviated preexposure rabies vaccination schedules that would reduce cost and shorten time required for completion. METHOD: A random prospective immunogenicity study, using a group of 96 volunteer preclinical veterinary students, primary school children, and hospital-based health care workers. They were divided into six groups and administered abbreviated schedules of preexposure tissue culture rabies vaccines. Neutralizing antibodies were determined on days 0 and 360, and following boosters on days 367 and 374. RESULTS: All subjects, including one group that received only 0.1 mL intradermally at two sites on one day, had detectable neutralizing antibody titers 1 year later and responded with an accelerated antibody response when given booster injections. CONCLUSION: It might be possible to develop a 1-week and even one clinic visit preexposure vaccine schedule that would provide at least 1 year of immune memory.
RCT Entities:
OBJECTIVE: To evaluate abbreviated preexposure rabies vaccination schedules that would reduce cost and shorten time required for completion. METHOD: A random prospective immunogenicity study, using a group of 96 volunteer preclinical veterinary students, primary school children, and hospital-based health care workers. They were divided into six groups and administered abbreviated schedules of preexposure tissue culture rabies vaccines. Neutralizing antibodies were determined on days 0 and 360, and following boosters on days 367 and 374. RESULTS: All subjects, including one group that received only 0.1 mL intradermally at two sites on one day, had detectable neutralizing antibody titers 1 year later and responded with an accelerated antibody response when given booster injections. CONCLUSION: It might be possible to develop a 1-week and even one clinic visit preexposure vaccine schedule that would provide at least 1 year of immune memory.
Authors: Jocelyn A Kessels; Sergio Recuenco; Ana Maria Navarro-Vela; Raffy Deray; Marco Vigilato; Hildegund Ertl; David Durrheim; Helen Rees; Louis H Nel; Bernadette Abela-Ridder; Deborah Briggs Journal: Bull World Health Organ Date: 2016-11-25 Impact factor: 9.408
Authors: Jenny L Schnyder; Cornelis A De Pijper; Hannah M Garcia Garrido; Joost G Daams; Abraham Goorhuis; Cornelis Stijnis; Frieder Schaumburg; Martin P Grobusch Journal: Travel Med Infect Dis Date: 2020-09-06 Impact factor: 6.211