| Literature DB >> 17434735 |
Hiroshi Maruoka1, Tsuyoshi Muto, Taisaku Tanaka, Seiichi Imajo, Yoshiaki Tomimori, Yoshiaki Fukuda, Takashi Nakatsuka.
Abstract
A novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones was designed, synthesized, and evaluated as human chymase inhibitors. From this series, we identified several compounds which were effective, via oral administration, in a mouse model of chronic dermatitis.Entities:
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Year: 2007 PMID： 17434735 DOI： 10.1016/j.bmcl.2007.03.085
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823