| Literature DB >> 17434734 |
Steven W Kortum1, Timothy E Benson, Michael J Bienkowski, Thomas L Emmons, D Bryan Prince, Donna J Paddock, Alfredo G Tomasselli, Joseph B Moon, Alice LaBorde, Ruth E TenBrink.
Abstract
The design and synthesis of a novel series of potent BACE1 hydroxyethylamine inhibitors. These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D.Entities:
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Year: 2007 PMID： 17434734 DOI： 10.1016/j.bmcl.2007.03.096
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823