Literature DB >> 17434479

Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647.

Roberto Russo1, Jesse LoVerme, Giovanna La Rana, Giuseppe D'Agostino, Oscar Sasso, Antonio Calignano, Daniele Piomelli.   

Abstract

The analgesic properties of cannabinoid receptor agonists are well characterized. However, numerous side effects limit the therapeutic potential of these agents. Here we report a synergistic antinociceptive interaction between the endogenous cannabinoid receptor agonist anandamide and the synthetic peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist 2-(4-(2-(1-Cyclohexanebutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid (GW7647) in a model of acute chemical-induced pain. Moreover, we show that anandamide synergistically interacts with the large-conductance potassium channel (KCa1.1, BK) activator isopimaric acid. These findings reveal a synergistic interaction between the endocannabinoid and PPAR-alpha systems that might be exploited clinically and identify a new pharmacological effect of the BK channel activator isopimaric acid.

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Year:  2007        PMID： 17434479      PMCID： PMC1997313          DOI： 10.1016/j.ejphar.2007.03.007

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  19 in total

Review 1.  A role for the endogenous cannabinoid system in the peripheral control of pain initiation.

Authors:  A Calignano; G La Rana; P Loubet-Lescoulié; D Piomelli
Journal:  Prog Brain Res       Date:  2000       Impact factor: 2.453

2.  Properties and functions of calcium-activated K+ channels in small neurones of rat dorsal root ganglion studied in a thin slice preparation.

Authors:  A Scholz; M Gruss; W Vogel
Journal:  J Physiol       Date:  1998-11-15       Impact factor: 5.182

3.  Prophylactic efficacy of N-2-hydroxyethyl palmitamide (impulsin) in acute respiratory tract infections.

Authors:  K Masek; F Perlík; J Klíma; R Kahlich
Journal:  Eur J Clin Pharmacol       Date:  1974-10-04       Impact factor: 2.953

4.  Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha.

Authors:  Jesse LoVerme; Roberto Russo; Giovanna La Rana; Jin Fu; Jesse Farthing; Giuseppina Mattace-Raso; Rosaria Meli; Andrea Hohmann; Antonio Calignano; Daniele Piomelli
Journal:  J Pharmacol Exp Ther       Date:  2006-09-22       Impact factor: 4.030

5.  Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide.

Authors:  A Calignano; G La Rana; D Piomelli
Journal:  Eur J Pharmacol       Date:  2001-05-11       Impact factor: 4.432

6.  Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit.

Authors:  Yuji Imaizumi; Kazuho Sakamoto; Aki Yamada; Aya Hotta; Susumu Ohya; Katsuhiko Muraki; Masanobu Uchiyama; Tomohiko Ohwada
Journal:  Mol Pharmacol       Date:  2002-10       Impact factor: 4.436

7.  Control of pain initiation by endogenous cannabinoids.

Authors:  A Calignano; G La Rana; A Giuffrida; D Piomelli
Journal:  Nature       Date:  1998-07-16       Impact factor: 49.962

8.  The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain.

Authors:  S I Jaggar; F S Hasnie; S Sellaturay; A S Rice
Journal:  Pain       Date:  1998-05       Impact factor: 6.961

Review 9.  Synergistic interactions between cannabinoid and opioid analgesics.

Authors:  Diana L Cichewicz
Journal:  Life Sci       Date:  2004-01-30       Impact factor: 5.037

10.  N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation.

Authors:  S Mazzari; R Canella; L Petrelli; G Marcolongo; A Leon
Journal:  Eur J Pharmacol       Date:  1996-04-11       Impact factor: 4.432
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  29 in total

1.  PPARα agonists--an emerging concept in the management of neuropathic and visceral pain.

Authors:  Shailendra Kapoor
Journal:  Psychopharmacology (Berl)       Date:  2012-03-30       Impact factor: 4.530

2.  Evaluation of fatty acid amides in the carrageenan-induced paw edema model.

Authors:  Laura E Wise; Roberta Cannavacciulo; Benjamin F Cravatt; Billy F Martin; Aron H Lichtman
Journal:  Neuropharmacology       Date:  2007-06-22       Impact factor: 5.250

Review 3.  The complications of promiscuity: endocannabinoid action and metabolism.

Authors:  S P H Alexander; D A Kendall
Journal:  Br J Pharmacol       Date:  2007-09-17       Impact factor: 8.739

4.  'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors.

Authors:  W-S V Ho; D A Barrett; M D Randall
Journal:  Br J Pharmacol       Date:  2008-08-11       Impact factor: 8.739

Review 5.  The endocannabinoid system and pain.

Authors:  Josée Guindon; Andrea G Hohmann
Journal:  CNS Neurol Disord Drug Targets       Date:  2009-12       Impact factor: 4.388

6.  Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage.

Authors:  Oscar Sasso; Marco Migliore; Damien Habrant; Andrea Armirotti; Clara Albani; Maria Summa; Guillermo Moreno-Sanz; Rita Scarpelli; Daniele Piomelli
Journal:  FASEB J       Date:  2015-03-10       Impact factor: 5.191

7.  Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse.

Authors:  Zuzana Justinova; Leigh V Panlilio; Guillermo Moreno-Sanz; Godfrey H Redhi; Alessia Auber; Maria E Secci; Paola Mascia; Tiziano Bandiera; Andrea Armirotti; Rosalia Bertorelli; Svetlana I Chefer; Chanel Barnes; Sevil Yasar; Daniele Piomelli; Steven R Goldberg
Journal:  Neuropsychopharmacology       Date:  2015-03-10       Impact factor: 7.853

8.  Discovery of Potent Dual PPARα Agonists/CB1 Ligands.

Authors:  Ruth Pérez-Fernández; Nieves Fresno; Manuel Macías-González; José Elguero; Juan Decara; Rocío Girón; Ana Rodríguez-Álvarez; María Isabel Martín; Fernando Rodríguez de Fonseca; Pilar Goya
Journal:  ACS Med Chem Lett       Date:  2011-09-16       Impact factor: 4.345

9.  Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models.

Authors:  Oscar Sasso; Guillermo Moreno-Sanz; Cataldo Martucci; Natalia Realini; Mauro Dionisi; Luisa Mengatto; Andrea Duranti; Glauco Tarozzo; Giorgio Tarzia; Marco Mor; Rosalia Bertorelli; Angelo Reggiani; Daniele Piomelli
Journal:  Pain       Date:  2012-11-02       Impact factor: 6.961

Review 10.  Dynamic regulation of the endocannabinoid system: implications for analgesia.

Authors:  Devi Rani Sagar; A Gemma Gaw; Bright N Okine; Stephen G Woodhams; Amy Wong; David A Kendall; Victoria Chapman
Journal:  Mol Pain       Date:  2009-10-08       Impact factor: 3.395
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