Literature DB >> 17433749

Evidence for function of UDP galactose pyrophosphorylase in mice with absent galactose-1-phosphate uridyltransferase.

Suzanne Wehrli1, Robert Reynolds, Stanton Segal.   

Abstract

Mice with deletion of the galactose-1-phosphate uridyltransferase (GALT) gene were examined for their ability to form (13)C labeled hepatic UDP glucose from administered 1-(13)C galactose. NMR analysis of urinary acetaminophen glucuronide, which is derived from hepatic UDP glucose showed (13)C enrichment after concomitant administration of (13)C galactose and acetaminophen. The finding is consistent with the function of UDP galactose pyrophosphorylase as an alternate pathway of galactose metabolism.

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Year:  2007        PMID： 17433749     DOI： 10.1016/j.ymgme.2007.02.013

Source DB:  PubMed          Journal:  Mol Genet Metab        ISSN： 1096-7192            Impact factor:   4.797


  3 in total

Review 1.  UDP-sugar pyrophosphorylase: a new old mechanism for sugar activation.

Authors:  Leszek A Kleczkowski; Daniel Decker; Malgorzata Wilczynska
Journal:  Plant Physiol       Date:  2011-03-28       Impact factor: 8.340

2.  Biomarkers of ovarian function in girls and women with classic galactosemia.

Authors:  Rebecca D Sanders; Jessica B Spencer; Michael P Epstein; Susan V Pollak; Pratibhasri A Vardhana; Joyce W Lustbader; Judith L Fridovich-Keil
Journal:  Fertil Steril       Date:  2008-08-05       Impact factor: 7.329

Review 3.  Pathophysiology and targets for treatment in hereditary galactosemia: A systematic review of animal and cellular models.

Authors:  Minela Haskovic; Ana I Coelho; Jörgen Bierau; Jo M Vanoevelen; Laura K M Steinbusch; Luc J I Zimmermann; Eduardo Villamor-Martinez; Gerard T Berry; M Estela Rubio-Gozalbo
Journal:  J Inherit Metab Dis       Date:  2020-01-14       Impact factor: 4.982
  3 in total

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