Mohamad Arafa1, Omar El Tabie. 1. Kasr AlEini Hospital-Cairo University-Department of Andrology, Cairo, Egypt. mohamedarafa@email.com
Abstract
INTRODUCTION: Retrograde ejaculation (RE) is one of the complications of diabetes mellitus. Different therapeutic approaches are present, whether medical or surgical, with limited success rates. AIM: The aim of the present study is to evaluate different drug regimens for the medical treatment of RE in diabetic patients. PATIENTS AND METHODS: Thirty-three diabetic patients with RE (23 complete and 10 partial) were included in the study. Patients were given three sequential courses of medical treatment: imipramine 25 mg twice/day, pseudoephidrine 120 mg twice/day, or combination of the two drugs. MAIN OUTCOME MEASURES: Establishment of antegrade ejaculate in cases with complete RE and improvement of semen quality in case of partial RE. RESULTS: In cases with complete RE, imipramine was successful in producing antegrade ejaculate in 10 patients (38.5%), while pseudoephedrine was successful in 11 patients (47.8%), and both drugs given together was successful in 16 patients (61.5%). In cases with partial RE, there was significant increase in the antegrade semen sample as regards semen volume, sperm count, total, and progressive motility with imipramine alone, pseudoephidrine alone, and both drugs. CONCLUSION: From the present study we can conclude that medical treatment for RE in diabetic patients is a promising method and should be the first line of treatment in these cases.
INTRODUCTION: Retrograde ejaculation (RE) is one of the complications of diabetes mellitus. Different therapeutic approaches are present, whether medical or surgical, with limited success rates. AIM: The aim of the present study is to evaluate different drug regimens for the medical treatment of RE in diabeticpatients. PATIENTS AND METHODS: Thirty-three diabeticpatients with RE (23 complete and 10 partial) were included in the study. Patients were given three sequential courses of medical treatment: imipramine 25 mg twice/day, pseudoephidrine 120 mg twice/day, or combination of the two drugs. MAIN OUTCOME MEASURES: Establishment of antegrade ejaculate in cases with complete RE and improvement of semen quality in case of partial RE. RESULTS: In cases with complete RE, imipramine was successful in producing antegrade ejaculate in 10 patients (38.5%), while pseudoephedrine was successful in 11 patients (47.8%), and both drugs given together was successful in 16 patients (61.5%). In cases with partial RE, there was significant increase in the antegrade semen sample as regards semen volume, sperm count, total, and progressive motility with imipramine alone, pseudoephidrine alone, and both drugs. CONCLUSION: From the present study we can conclude that medical treatment for RE in diabeticpatients is a promising method and should be the first line of treatment in these cases.
Authors: Paolo Capogrosso; Christian Fuglesang S Jensen; Giulia Rastrelli; Josep Torremade; Giorgio I Russo; Amr Abdel Raheem; Anders Frey; Mikkel Fode; Mario Maggi; Yacov Reisman; Carlo Bettocchi; Giovanni Corona Journal: Sex Med Date: 2021-06-02 Impact factor: 2.491