Literature DB >> 17431381

Expression of CD40 and CD40L on tumor cells: the role of their interaction and new approach to immunotherapy.

N M Bereznaya1, V F Chekhun.   

Abstract

In the review the modern insights on the role of expression of CD40 and CD40L and the role of their interaction on tumor cells growth are analyzed. Information about the structure and biologic properties of these molecules and their interaction is presented. The question on the role of CD40/CD40L interaction is highlighted in two aspects--the possibility of tumor growth inhibition and its stimulation. According to the mentioned aspects, immunologic mechanisms providing tumor growth inhibition (the role of dendritic cells, macrophages, monocytes, cytotoxic T-lymphocytes, natural killer cells etc.), and also the possibility of apoptotic events are discussed. Possibility of tumor growth stimulation upon the influence of CD40/CD40L interaction that could occur in some cases is analyzed as well. The data of literature about new approaches to immunotherapy of cancer based on CD40/CD40L interactionare summarized.

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Year:  2007        PMID： 17431381

Source DB:  PubMed          Journal:  Exp Oncol        ISSN： 1812-9269


  9 in total

1.  High plasma CD40 ligand level is associated with more advanced stages and worse prognosis in colorectal cancer.

Authors:  Zoltan Herold; Magdolna Herold; Gyorgy Herczeg; Agnes Fodor; Attila Marcell Szasz; Magdolna Dank; Aniko Somogyi
Journal:  World J Clin Cases       Date:  2022-05-06       Impact factor: 1.534

2.  Inhibition of CD40-CD154 costimulatory pathway by a cyclic peptide targeting CD154.

Authors:  Ilaria Deambrosis; Sara Lamorte; Fulvia Giaretta; Lorenzo Tei; Luigi Biancone; Benedetta Bussolati; Giovanni Camussi
Journal:  J Mol Med (Berl)       Date:  2008-11-05       Impact factor: 4.599

3.  Low expression of CD40L in tumor-free lymph node of oral cavity cancer related with poor prognosis.

Authors:  Yoon Chan Rah; Jae-Cheul Ahn; Eun-Hui Jeon; Hyojin Kim; Jin Ho Paik; Woo-Jin Jeong; Soon-Young Kwon; Soon-Hyun Ahn
Journal:  Int J Clin Oncol       Date:  2018-05-14       Impact factor: 3.402

4.  Increase in tumour-infiltrating lymphocytes with regulatory T cell immunophenotypes and reduced zeta-chain expression in nasopharyngeal carcinoma patients.

Authors:  W K Yip; M A Abdullah; S M Yusoff; H F Seow
Journal:  Clin Exp Immunol       Date:  2009-03       Impact factor: 4.330

5.  Cationic liposome-mediated transfection of CD40 ligand gene inhibits hepatic tumor growth of hepatocellular carcinoma in mice.

Authors:  Yong-fang Jiang; Jing Ma; Yan He; Yong-hong Zhang; Yun Xu; Guo-zhong Gong
Journal:  J Zhejiang Univ Sci B       Date:  2009-01       Impact factor: 3.066

6.  TNF-α promotes IFN-γ-induced CD40 expression and antigen process in Myb-transformed hematological cells.

Authors:  Wenyi Gu; Jiezhong Chen; Lei Yang; Kong-Nan Zhao
Journal:  ScientificWorldJournal       Date:  2012-04-01

7.  Multifunctional CD40L: pro- and anti-neoplastic activity.

Authors:  Aleksandra Korniluk; Halina Kemona; Violetta Dymicka-Piekarska
Journal:  Tumour Biol       Date:  2014-08-13

Review 8.  Interaction Networks Converging on Immunosuppressive Roles of Granzyme B: Special Niches Within the Tumor Microenvironment.

Authors:  Weinan Wang; Rui Zou; Ye Qiu; Jishuang Liu; Yu Xin; Tianzhu He; Zhidong Qiu
Journal:  Front Immunol       Date:  2021-04-01       Impact factor: 7.561

9.  Double Strike Approach for Tumor Attack: Engineering T Cells Using a CD40L:CD28 Chimeric Co-Stimulatory Switch Protein for Enhanced Tumor Targeting in Adoptive Cell Therapy.

Authors:  Luis Felipe Olguín-Contreras; Anna N Mendler; Grzegorz Popowicz; Bin Hu; Elfriede Noessner
Journal:  Front Immunol       Date:  2021-11-29       Impact factor: 7.561
  9 in total

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