Literature DB >> 1743072

Localization of the gene encoding insulin-degrading enzyme to human chromosome 10, bands q23----q25.

R Espinosa1, R S Lemons, R K Perlman, W L Kuo, M R Rosner, M M Le Beau.   

Abstract

Insulin-degrading enzyme (IDE) is a cytosolic proteinase involved in the cellular processing of insulin. Using somatic cell hybrid analysis and in situ chromosomal hybridization, we have localized the gene encoding IDE to human chromosome 10, bands q23----q25. The murine Ide gene was previously mapped to Chromosome 19; together, these results suggest that the IDE gene is a member of a conserved syntenic group on human chromosome 10, bands q23----q25 and mouse Chromosome 19.

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Year:  1991        PMID： 1743072     DOI： 10.1159/000133142

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  7 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q.

Authors:  S Wiltshire; A T Hattersley; G A Hitman; M Walker; J C Levy; M Sampson; S O'Rahilly; T M Frayling; J I Bell; G M Lathrop; A Bennett; R Dhillon; C Fletcher; C J Groves; E Jones; P Prestwich; N Simecek; P V Rao; M Wishart; G F Bottazzo; R Foxon; S Howell; D Smedley; L R Cardon; S Menzel; M I McCarthy
Journal:  Am J Hum Genet       Date:  2001-08-01       Impact factor: 11.025

3.  Quantitative loci regulating plasma levels of gamma glutamyl transferase and albumin and their genetic correlations with cardiovascular risk factors.

Authors:  Tanushree Bose; V Saroja Voruganti; M Elizabeth Tejero; J Michael Proffitt; Laura A Cox; John L VandeBerg; Michael C Mahaney; Jeffrey Rogers; Jeanne H Freeland-Graves; Shelley A Cole; Anthony G Comuzzie
Journal:  Exp Biol Med (Maywood)       Date:  2009-12

4.  Regulation of beta-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease.

Authors:  R P Jaya Prasanthi; Eric Schommer; Sarah Thomasson; Alex Thompson; Gwen Feist; Othman Ghribi
Journal:  Mech Ageing Dev       Date:  2008-09-19       Impact factor: 5.432

5.  Disorder-specific effects of polymorphisms at opposing ends of the Insulin Degrading Enzyme gene.

Authors:  Jasmin Bartl; Claus-Jürgen Scholz; Margareta Hinterberger; Susanne Jungwirth; Ildiko Wichart; Michael K Rainer; Susanne Kneitz; Walter Danielczyk; Karl H Tragl; Peter Fischer; Peter Riederer; Edna Grünblatt
Journal:  BMC Med Genet       Date:  2011-11-22       Impact factor: 2.103

6.  Somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD.

Authors:  Grazia Tundo; Chiara Ciaccio; Diego Sbardella; Mariaserena Boraso; Barbara Viviani; Massimiliano Coletta; Stefano Marini
Journal:  PLoS One       Date:  2012-04-03       Impact factor: 3.240

7.  beta-Amyloid degradation and Alzheimer's disease.

Authors:  Deng-Shun Wang; Dennis W Dickson; James S Malter
Journal:  J Biomed Biotechnol       Date:  2006
  7 in total

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