OBJECTIVES: To examine the spectrum of alcohol and substance abuse, including reasons for use, in patients with bipolar I disorder, compared with patients with substance use disorder and healthy controls, with a specific focus on the relationship between substance use, substance sensitivity, other comorbid psychiatric symptoms and traits related to sensation seeking. METHODS: This study included 104 patients with bipolar I disorder (BPD I), of whom 57 (54.8%) met DSM-IV criteria for lifetime alcohol or substance use disorder (BPD + SUD), 35 patients with substance use disorder (SUD) and no psychiatric disorder and 50 healthy controls. Assessments included the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) and the Structured Clinical Interview for the Spectrum of Substance Use (SCI-SUBS). RESULTS: Patients with BPD + SUD and SUD had significantly higher scores on the SCI-SUBS domains of self-medication, substance sensitivity and sensation seeking compared with patients with BPD and healthy controls. Reasons for substance use did not differ between patients with BPD + SUD and patients with SUD. Those most frequently cited were: improving mood; relieving tension; alleviating boredom; achieving/maintaining euphoria; and increasing energy. CONCLUSIONS: Recourse to substances is associated with increased mood and anxiety symptoms, substance sensitivity, and sensation seeking among patients with BPD + SUD and SUD. Substance sensitivity and sensation seeking traits should be investigated in all patients with BPD as possible factors associated with a development of SUD, in order to warn patients of the specific risks related to improper use of medications and substances.
OBJECTIVES: To examine the spectrum of alcohol and substance abuse, including reasons for use, in patients with bipolar I disorder, compared with patients with substance use disorder and healthy controls, with a specific focus on the relationship between substance use, substance sensitivity, other comorbid psychiatric symptoms and traits related to sensation seeking. METHODS: This study included 104 patients with bipolar I disorder (BPD I), of whom 57 (54.8%) met DSM-IV criteria for lifetime alcohol or substance use disorder (BPD + SUD), 35 patients with substance use disorder (SUD) and no psychiatric disorder and 50 healthy controls. Assessments included the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) and the Structured Clinical Interview for the Spectrum of Substance Use (SCI-SUBS). RESULTS:Patients with BPD + SUD and SUD had significantly higher scores on the SCI-SUBS domains of self-medication, substance sensitivity and sensation seeking compared with patients with BPD and healthy controls. Reasons for substance use did not differ between patients with BPD + SUD and patients with SUD. Those most frequently cited were: improving mood; relieving tension; alleviating boredom; achieving/maintaining euphoria; and increasing energy. CONCLUSIONS: Recourse to substances is associated with increased mood and anxiety symptoms, substance sensitivity, and sensation seeking among patients with BPD + SUD and SUD. Substance sensitivity and sensation seeking traits should be investigated in all patients with BPD as possible factors associated with a development of SUD, in order to warn patients of the specific risks related to improper use of medications and substances.
Authors: Jacob R Stephens; Jaimee L Heffner; Caleb M Adler; Thomas J Blom; Robert M Anthenelli; David E Fleck; Jeffrey A Welge; Stephen M Strakowski; Melissa P DelBello Journal: J Am Acad Child Adolesc Psychiatry Date: 2014-05-10 Impact factor: 8.829
Authors: Benjamin I Goldstein; Tina R Goldstein; Katelyn A Collinger; David A Axelson; Oscar G Bukstein; Boris Birmaher; David J Miklowitz Journal: J Psychiatr Pract Date: 2014-05 Impact factor: 1.325
Authors: Leslie A Hulvershorn; Jennifer King; Patrick O Monahan; Holly C Wilcox; Philip B Mitchell; Janice M Fullerton; Howard J Edenberg; Gloria M P Roberts; Masoud Kamali; Anne L Glowinski; Neera Ghaziuddin; Melvin McInnis; Priya A Iyer-Eimerbrink; John I Nurnberger Journal: Compr Psychiatry Date: 2017-07-27 Impact factor: 3.735
Authors: Maria A Oquendo; Dianne Currier; Shang-Min Liu; Deborah S Hasin; Bridget F Grant; Carlos Blanco Journal: J Clin Psychiatry Date: 2010-07 Impact factor: 4.384
Authors: Jony Sheynin; Ahmed A Moustafa; Kevin D Beck; Richard J Servatius; Peter A Casbolt; Paul Haber; Mahmoud Elsayed; Lee Hogarth; Catherine E Myers Journal: J Clin Psychiatry Date: 2016-03 Impact factor: 4.384