Literature DB >> 17430212

Chemical modifications to improve the cellular uptake of oligonucleotides.

Françoise Debart1, Saïd Abes, Gaelle Deglane, Hong M Moulton, Philippe Clair, Michael J Gait, Jean-Jacques Vasseur, Bernard Lebleu.   

Abstract

Specific control of gene expression by synthetic oligonucleotides (ON) is now widely used for target validation but clinical applications are limited by ON bioavailability. Moreover, most currently used strategies for physical and chemical delivery cannot be easily implemented in vivo. This article reviews new strategies which appear promising for ON delivery. The first part deals with ON chemical modifications aiming at improving cellular uptake as for instance the grafting of cationic groups on the ON backbone. The second part concerns ON conjugation to cell penetrating peptides.

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Year:  2007        PMID： 17430212     DOI： 10.2174/156802607780487704

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  9 in total

1.  Cellular uptake, tissue penetration, biodistribution, and biosafety of threose nucleic acids: Assessing in vitro and in vivo delivery.

Authors:  Fei Wang; Ling Sum Liu; Pan Li; Cia Hin Lau; Hoi Man Leung; Y Rebecca Chin; Chung Tin; Pik Kwan Lo
Journal:  Mater Today Bio       Date:  2022-05-18

2.  Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs.

Authors:  Qing Ge; Anne Dallas; Heini Ilves; Joshua Shorenstein; Mark A Behlke; Brian H Johnston
Journal:  RNA       Date:  2009-11-30       Impact factor: 4.942

3.  Quantum mechanical studies of DNA and LNA.

Authors:  Troels Koch; Irene Shim; Morten Lindow; Henrik Ørum; Henrik G Bohr
Journal:  Nucleic Acid Ther       Date:  2014-02-03       Impact factor: 5.486

4.  Direct cytosolic delivery of polar cargo to cells by spontaneous membrane-translocating peptides.

Authors:  Jing He; W Berkeley Kauffman; Taylor Fuselier; Somanna K Naveen; Thomas G Voss; Kalina Hristova; William C Wimley
Journal:  J Biol Chem       Date:  2013-08-27       Impact factor: 5.157

5.  Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor.

Authors:  Xin Ming; Md Rowshon Alam; Michael Fisher; Yongjun Yan; Xiaoyuan Chen; Rudolph L Juliano
Journal:  Nucleic Acids Res       Date:  2010-06-15       Impact factor: 16.971

6.  2'-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity.

Authors:  Dmytro Honcharenko; Cristina S J Rocha; Karin E Lundin; Jyotirmoy Maity; Stefan Milton; Ulf Tedebark; Merita Murtola; Malgorzata Honcharenko; Andis Slaitas; C I Edvard Smith; Rula Zain; Roger Strömberg
Journal:  Nucleic Acid Ther       Date:  2022-03-02       Impact factor: 4.244

7.  Non-Nucleosidic Analogues of Polyaminonucleosides and Their Influence on Thermodynamic Properties of Derived Oligonucleotides.

Authors:  Jolanta Brzezinska; Wojciech T Markiewicz
Journal:  Molecules       Date:  2015-07-13       Impact factor: 4.411

8.  Solid-phase-supported synthesis of morpholinoglycine oligonucleotide mimics.

Authors:  Tatyana V Abramova; Sergey S Belov; Yulia V Tarasenko; Vladimir N Silnikov
Journal:  Beilstein J Org Chem       Date:  2014-05-20       Impact factor: 2.883

Review 9.  Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses.

Authors:  Kevin B Spurgers; C Matthew Sharkey; Kelly L Warfield; Sina Bavari
Journal:  Antiviral Res       Date:  2008-01-14       Impact factor: 5.970
  9 in total

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